膜动力学和细胞器生物发生-脂质管道和囊泡载体。

MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London, WC1E 6BT, UK.

Cell Biology Program, The Hospital for Sick Children and Department of Biochemistry, University of Toronto, Toronto, Canada.

BMC Biol. 2017 Oct 31;15(1):102. doi: 10.1186/s12915-017-0432-0.

Discoveries spanning several decades have pointed to vital membrane lipid trafficking pathways involving both vesicular and non-vesicular carriers. But the relative contributions for distinct membrane delivery pathways in cell growth and organelle biogenesis continue to be a puzzle. This is because lipids flow from many sources and across many paths via transport vesicles, non-vesicular transfer proteins, and dynamic interactions between organelles at membrane contact sites. This forum presents our latest understanding, appreciation, and queries regarding the lipid transport mechanisms necessary to drive membrane expansion during organelle biogenesis and cell growth.

几十年来的研究发现，涉及囊泡和非囊泡载体的重要膜脂运输途径。但是，不同膜递呈途径在细胞生长和细胞器生物发生中的相对贡献仍然是一个谜。这是因为脂质从许多来源通过运输囊泡、非囊泡转移蛋白以及膜接触部位细胞器之间的动态相互作用，沿着许多路径流动。本次论坛介绍了我们对驱动细胞器生物发生和细胞生长过程中膜扩张所需的脂质运输机制的最新理解、认识和疑问。