对以多剂量方式使用的单剂量药物的无菌性评估。
Evaluation of the sterility of single-dose medications used in a multiple-dose fashion.
作者信息
Martin Elizabeth P, Mukherjee Jean, Sharp Claire R, Sinnott-Stutzman Virginia B
机构信息
Cape Cod Veterinary Specialists, 11 Bourne Bridge Approach, Buzzards Bay, Massachusetts 02532, USA (Martin); Tufts University Cummings School of Veterinary Medicine, 200 Westboro Road, North Grafton, Massachusetts 01536, USA (Mukherjee); College of Veterinary Medicine, School of Veterinary and Life Sciences, Murdoch University, 90 South Street, Murdoch, Western Australia 6150 (Sharp); Angell Animal Medical Center, 350 S Huntington Avenue, Boston, Massachusetts 02130, USA (Sinnott-Stutzman).
出版信息
Can Vet J. 2017 Nov;58(11):1187-1190.
Bacterial proliferation was evaluated in single-dose medications used in a multi-dose fashion and when medications were intentionally inoculated with bacteria. Of 5 experimentally punctured medications, 1 of 75 vials (50% dextrose) became contaminated. When intentionally inoculated, hydroxyethyl starch and heparinized saline supported microbial growth. Based on these findings, it is recommended that hydroxyethyl starch and heparinized saline not be used in a multi-dose fashion.
对以多剂量方式使用的单剂量药物以及故意接种细菌的药物中的细菌增殖情况进行了评估。在5种经实验穿刺的药物中，75个小瓶中有1个（50%葡萄糖）被污染。当故意接种时，羟乙基淀粉和肝素盐水支持微生物生长。基于这些发现，建议不要以多剂量方式使用羟乙基淀粉和肝素盐水。
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