Razeghinejad Mohammad Reza, Tajbakhsh Zahra, Nowroozzadeh Mohammad Hossein, Masoumpour Masoumeh
Poostchi Ophthalmology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Glaucoma Service, Wills Eye Hospital, Philadelphia, PA, USA.
J Ophthalmic Vis Res. 2017 Oct-Dec;12(4):390-396. doi: 10.4103/jovr.jovr_204_16.
To study the effects of filtration surgeries (tube and trabeculectomy) on changes in intraocular pressure after a water-drinking test.
In this prospective, non-randomized, comparative clinical study, 30 patients who had tube surgery and 30 age- and sex-matched trabeculectomy patients underwent a water-drinking test. Only one eye of each patient was included. The baseline intraocular pressure was ≤21 mmHg in all enrolled eyes with or without adjunctive topical medications. After the water-drinking test, the intraocular pressure was measured and recorded at 15, 30, 45, and 60 minutes and the results were compared between the two groups.
In both groups, intraocular pressure significantly increased from baseline at all measured time-points ( < 0.001). In the trabeculectomy group, the average intraocular pressure increased from 14.8 ± 2.9 to 18.8 ± 4.7 mmHg at 30 minutes, but decreased at 60 min (18.0 ± 5.2 mmHg). In the Tube group, intraocular pressure increased incrementally until the last measurement (14.2 ± 3.9, 18.8 ± 5.6, and 19.7 ± 6.0 mmHg at baseline, 30, and 60 minutes, respectively). The end-pressure difference (intraocular pressure at 60 minutes vs. baseline) was significantly greater in the tube group (5.6 ± 3.6 mmHg; 41% change) than in the trabeculectomy group (3.2 ± 4.7; 23% change; = 0.03).
Intraocular pressure significantly increased after the water-drinking test in both the groups. Intraocular pressure started to decline 30 minutes after the water-drinking test in the trabeculectomy group, while it continued to increase up to 60 minutes in the Tube group. This finding may have implications regarding the efficacy or safety of the procedures in advanced glaucoma patients.
研究滤过性手术（引流管植入术和小梁切除术）对饮水试验后眼压变化的影响。
在这项前瞻性、非随机、对照临床研究中，30例行引流管植入术的患者和30例年龄及性别匹配的小梁切除术患者接受了饮水试验。每位患者仅纳入一只眼。所有纳入研究的眼，无论是否使用辅助局部药物，基线眼压均≤21 mmHg。饮水试验后，分别于15、30、45和60分钟测量并记录眼压，并比较两组结果。
两组在所有测量时间点的眼压均较基线显著升高（<0.001）。小梁切除术组，30分钟时平均眼压从14.8±2.9 mmHg升高至18.8±4.7 mmHg，但60分钟时下降（18.0±5.2 mmHg）。引流管植入术组，眼压持续升高直至最后一次测量（基线、30分钟和60分钟时分别为14.2±3.9 mmHg、18.8±5.6 mmHg和19.7±6.0 mmHg）。引流管植入术组的终末眼压差值（60分钟时眼压与基线眼压之差）显著大于小梁切除术组（5.6±3.6 mmHg；变化41%）（小梁切除术组为3.2±4.7 mmHg；变化；23%；P = 0.03）。
两组饮水试验后眼压均显著升高。小梁切除术组在饮水试验30分钟后眼压开始下降，而引流管植入术组眼压持续升高至60分钟。这一发现可能对晚期青光眼患者手术的疗效或安全性具有重要意义。
