Susanna Carolina Nicolela, Susanna Bianca Nicolela, Susanna Fernanda Nicolela, Susanna Remo, De Moraes Carlos Gustavo
Department of Ophthalmology, ABC Foundation School of Medicine, Santo André, Brazil.
Department of Ophthalmology, University of Sao Paulo School of Medicine, Sao Paulo, Brazil.
J Ophthalmic Vis Res. 2022 Jan 21;17(1):27-32. doi: 10.18502/jovr.v17i1.10167. eCollection 2022 Jan-Mar.
To investigate the association between the time of occurrence of intraocular pressure (IOP) peaks during the water-drinking test (WDT) and visual field damage in a cohort of primary open-angle glaucoma (POAG) patients.
In this retrospective, cross-sectional study, 98 eyes from 49 consecutive POAG patients were followed in a referral clinical practice. The relationship between the time when IOP peaks occurred during the WDT and the visual field mean deviation (MD) assessed with 24-2 visual field was tested with mixed-effects models.
MD value was significantly associated with the time of IOP peak occurrence ( = 0.020) when adjusting for the number of medications, but not with the IOP peak values ( 0.238).
The time of IOP peaks occurrence during the WDT was associated with glaucoma severity among treated POAG patients.
在一组原发性开角型青光眼（POAG）患者中，研究饮水试验（WDT）期间眼压（IOP）峰值出现时间与视野损害之间的关联。
在这项回顾性横断面研究中，对一家转诊临床机构中连续49例POAG患者的98只眼睛进行了随访。采用混合效应模型检验了WDT期间IOP峰值出现时间与用24-2视野评估的视野平均偏差（MD）之间的关系。
在调整用药数量后，MD值与IOP峰值出现时间显著相关（P = 0.020），但与IOP峰值无关（P = 0.238）。
在接受治疗的POAG患者中，WDT期间IOP峰值出现时间与青光眼严重程度相关。
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