Anderson Zoe J, Hobson Christian, Needley Rebecca, Song Lijiang, Perryman Michael S, Kerby Paul, Fox David J
Department of Chemistry, University of Warwick, Gibbet Hill Road, Coventry, CV4 7AL, UK.
Org Biomol Chem. 2017 Nov 15;15(44):9372-9378. doi: 10.1039/c7ob01995e.
A simple H and C NMR spectrometric analysis is demonstrated that permits differentiation of isoleucine and allo-isoleucine residues by inspection of the chemical shift and coupling constants of the signals associated with the proton and carbon at the α-stereocentre. This is applied to the estimation of epimerisation during metal-free N-arylation and peptide coupling reactions.
已证明一种简单的氢和碳核磁共振光谱分析方法，通过检查与α-立体中心的质子和碳相关信号的化学位移和耦合常数，能够区分异亮氨酸和别异亮氨酸残基。这被应用于无金属N-芳基化和肽偶联反应过程中差向异构化的估计。
