Rosenthal D I, Mayo-Smith W, Goodsitt M M, Doppelt S, Mankin H J
Department of Radiology, Massachusetts General Hospital, Boston 02114.
Radiology. 1989 Jan;170(1 Pt 1):143-6. doi: 10.1148/radiology.170.1.2909087.
The trabecular bone density and bone marrow fat content in eight patients with type 1 Gaucher disease were measured with the use of a modification of dual-energy computed tomography (CT). The results were compared with those in published reports of single-energy quantitative CT measurements in healthy subjects and with dual-energy data obtained in studies of healthy premenopausal women and elderly osteopenic women. The trabecular bone mass was moderately decreased in patients with Gaucher disease. The bone marrow fat content was markedly diminished, presumably due to replacement of marrow fat by Gaucher cells. In healthy and osteopenic subjects single-energy quantitative CT values were lowered by the presence of marrow fat. Comparable single-energy measurements in patients with Gaucher disease reflect greater degrees of bone loss. Low levels of marrow fat may prove to be a valuable marker of the severity of marrow disease.
采用改良双能计算机断层扫描（CT）对8例1型戈谢病患者的小梁骨密度和骨髓脂肪含量进行了测量。将结果与已发表的关于健康受试者单能定量CT测量的报告结果以及健康绝经前女性和老年骨质疏松女性研究中获得的双能数据进行了比较。戈谢病患者的小梁骨量中度降低。骨髓脂肪含量明显减少，可能是由于戈谢细胞取代了骨髓脂肪。在健康和骨质疏松受试者中，骨髓脂肪的存在会降低单能定量CT值。戈谢病患者可比的单能测量结果反映了更大程度的骨质流失。低水平的骨髓脂肪可能被证明是骨髓疾病严重程度的一个有价值的标志物。
