Laboratoire de Chimie Organique, Institute of Chemistry, Biology and Innovation (CBI)-UMR 8231, ESPCI Paris/CNRS/PSL Research University, 10 rue Vauquelin 75231 Paris Cedex 05, France.
Org Lett. 2017 Nov 17;19(22):6068-6071. doi: 10.1021/acs.orglett.7b02848. Epub 2017 Nov 1.
A cobalt-catalyzed cross-coupling between α-bromo amides and Grignard reagents is disclosed. The reaction is general and allows access to a large variety of α-aryl and β,γ-unsaturated amides. Some mechanistic investigations have been undertaken to determine the nature of the intermediate species.
公开了一种钴催化的α-溴代酰胺和格氏试剂的交叉偶联反应。该反应具有普遍性，可以得到各种α-芳基和β,γ-不饱和酰胺。进行了一些机理研究以确定中间物种的性质。
