利用整合膜孔和阻滞剂作为分子调节剂对膜通透性进行编程。
Programming membrane permeability using integrated membrane pores and blockers as molecular regulators.
作者信息
Thomas Julia M, Friddin Mark S, Ces Oscar, Elani Yuval
机构信息
Department of Chemistry, Imperial College London, Exhibition Road, London, SW7 2AZ, UK.
出版信息
Chem Commun (Camb). 2017 Nov 14;53(91):12282-12285. doi: 10.1039/c7cc05423h.
PMID:29091084
Abstract
We report a bottom-up synthetic biology approach to engineering vesicles with programmable permeabilities. Exploiting the concentration-dependent relationship between constitutively active pores (alpha-hemolysin) and blockers allows blockers to behave as molecular regulators for tuning permeability, enabling us to systematically modulate cargo release kinetics without changing the lipid fabric of the system.
摘要
我们报告了一种自下而上的合成生物学方法，用于构建具有可编程渗透性的囊泡。利用组成型活性孔（α-溶血素）与阻滞剂之间的浓度依赖关系，可使阻滞剂充当调节渗透性的分子调节剂，从而使我们能够在不改变系统脂质结构的情况下系统地调节货物释放动力学。
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