From the Department of Radiology, Seoul National University Hospital, Seoul, Republic of Korea (K.M.K., S.H.C., T.J.Y., J.h.K., C.H.S.); Department of Radiology, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul 110-744, Republic of Korea (S.H.C., C.H.S.); Institute of Radiation Medicine, Seoul National University Medical Research Center, Seoul, Republic of Korea (S.H.C.); Center for Nanoparticle Research, Institute for Basic Science, Seoul, Republic of Korea (S.H.C.); and GE Healthcare Korea, Seoul, Republic of Korea (M.H.).
Radiology. 2018 Apr;287(1):258-266. doi: 10.1148/radiol.2017162852. Epub 2017 Nov 1.
Purpose To determine the association between the administration of the macrocyclic contrast medium gadobutrol and T1 relaxation time in the brains of patients with normal renal function by using multidynamic multiecho (MDME) magnetic resonance (MR) imaging sequences. Materials and Methods The institutional review board approved this retrospective study, and the need to obtain written informed consent was waived. This study included 46 patients (revealed by an electronic medical record search) who had received one or more gadobutrol injections and a maximum of one MR imaging contrast medium injection other than gadobutrol before MDME sequence acquisition. One radiologist performed quantitative analyses of regions of interest on quantitative T1 maps twice to cover the normal-appearing globus pallidus (GP), frontal white matter, frontal cortex, and thalamus. The number of administrations and the cumulative dose of gadobutrol, age, intervals between administrations, sex, and treatment were investigated. Univariable and multivariable linear regression analyses of the T1 values in four brain regions and the GP-to-thalamus signal intensity (SI) ratio were performed. P values of less than the Bonferroni-corrected value of .01 were considered to indicate significant differences. Results Intraobserver reproducibility was good to excellent (intraclass correlation coefficients, 0.62-0.81). Because of high multicollinearity between the number of gadobutrol administrations and accumulated dose (r = 0.96, P < .001), the number of gadobutrol administrations was considered in the regression analyses. T1 shortening in the GP was independently associated with the number of gadobutrol administrations (P = .002). T1 in the other brain regions and the GP-to-thalamus SI ratio were not significantly associated with the number of gadobutrol administrations (P > .01). Conclusion Multiple exposures to gadobutrol are associated with T1 shortening in the GP. RSNA, 2017 Online supplemental material is available for this article.
目的 利用多动态多回波（MDME）磁共振（MR）成像序列，确定肾功能正常患者中给予大环类对比剂钆布醇与 T1 弛豫时间之间的相关性。
材料与方法 本机构审查委员会批准了这项回顾性研究，并且免除了获得书面知情同意的要求。这项研究纳入了 46 例（通过电子病历搜索发现）患者，这些患者在 MDME 序列采集前接受了 1 次或多次钆布醇注射，并且最多接受了 1 次除钆布醇之外的其他 MR 成像对比剂注射。1 位放射科医生对定量 T1 图上的感兴趣区进行了 2 次定量分析，以覆盖正常表现的苍白球（GP）、额白质、额皮质和丘脑。研究调查了钆布醇的给药次数和累积剂量、年龄、给药间隔、性别和治疗情况。对 4 个脑区的 T1 值和 GP-丘脑信号强度（SI）比值进行了单变量和多变量线性回归分析。将 P 值<Bonferroni 校正值的 0.01 定义为有统计学差异。
结果 观察者内重复性良好至极好（组内相关系数为 0.62-0.81）。由于钆布醇给药次数与累积剂量之间高度共线性（r = 0.96，P<0.001），所以在回归分析中考虑了钆布醇给药次数。GP 中的 T1 缩短与钆布醇给药次数独立相关（P =.002）。其他脑区和 GP-丘脑 SI 比值与钆布醇给药次数无显著相关性（P >.01）。
结论 多次接触钆布醇与 GP 中的 T1 缩短相关。
RSNA，2017
在线补充材料为本文提供。
