From the Department of Diagnostic Imaging and Radiology, University of Alberta Hospital, 8215 112 St NW, Edmonton, AB, Canada T6G 2B7 (R.B.); Division of Neurosurgery, Department of Surgery, University of Saskatchewan, Saskatoon, Canada (A.R.L.P.); and Departments of Science (N.K.B.) and Pediatrics (M.H.), University of Alberta, Edmonton, Canada.
Radiology. 2018 Oct;289(1):204-209. doi: 10.1148/radiol.2018172988. Epub 2018 Jun 26.
Purpose To determine whether multiple doses of gadobutrol increase the T1 signal intensity in the brains of children. Materials and Methods This retrospective imaging study evaluated 91 children (median age, 5.4 years; age range, 0-17 years) with brain tumors who underwent five or more MR brain examinations at a single institution. A subgroup of 46 patients received five or more administrations of gadobutrol (0.1 mmol/kg) and underwent follow-up MRI. T1 signal intensity in the globus pallidus and dentate nucleus was measured at the first to sixth unenhanced MR brain examination in these children. Globus pallidus-to-corpus callosum and dentate nucleus-to-corpus callosum signal intensity ratios were analyzed by linear mixed-effect analysis. Subgroup analysis was performed for six children who underwent 14 or more administrations of gadobutrol. Results The globus pallidus-to-corpus callosum ratio increased with patient age (absolute change, 0.0052 per year; 95% confidence interval: 0.0033, 0.0071; P < .0001). There was no change in the dentate nucleus-to-corpus callosum ratio with age (P = .30). Among 46 children who received five or more doses of gadobutrol (median dose, 11 mL; range, 3.9-31 mL), there was no change in signal intensity ratio of the globus pallidus (P = .17) or dentate nucleus (P = .44). Among six children who underwent more than 14 administrations of gadobutrol (median dose, 64 mL; range, 40-91 mL) there was no change in signal intensity ratio of the globus pallidus (P = .15) or dentate nucleus (P = .50). Conclusion No increase in T1-weighted signal intensity ratio was observed in the globus pallidus or dentate nucleus after the administration of at least five doses of gadobutrol. © RSNA, 2018 Online supplemental material is available for this article.
目的 确定多次注射钆布醇是否会增加儿童脑部的 T1 信号强度。
材料与方法 本回顾性影像学研究评估了在一家机构接受 5 次或以上磁共振脑检查的 91 名脑肿瘤患儿（中位年龄为 5.4 岁；年龄范围为 0-17 岁）。其中，46 名患儿接受了 5 次或以上的钆布醇（0.1mmol/kg）给药，并进行了随访 MRI 检查。在这些患儿的首次至第 6 次未增强磁共振脑检查中，测量了苍白球和齿状核的 T1 信号强度。通过线性混合效应分析，对接受了 14 次或以上钆布醇给药的 6 名患儿进行了亚组分析。
结果 苍白球与胼胝体的信号强度比值随患儿年龄的增长而增加（绝对变化，每年 0.0052；95%置信区间：0.0033，0.0071；P<0.0001）。年龄与齿状核与胼胝体的信号强度比值之间无变化（P=0.30）。在接受了 5 次或以上钆布醇给药的 46 名患儿中（中位剂量为 11ml；范围为 3.9-31ml），苍白球信号强度比值无变化（P=0.17）或齿状核信号强度比值无变化（P=0.44）。在接受了 14 次以上钆布醇给药的 6 名患儿中（中位剂量为 64ml；范围为 40-91ml），苍白球或齿状核的信号强度比值无变化（P=0.15）或齿状核信号强度比值无变化（P=0.50）。
结论 在至少 5 次钆布醇给药后，苍白球或齿状核的 T1 加权信号强度比值未见增加。
