Murton Olivia M, Hillman Robert E, Mehta Daryush D, Semigran Marc, Daher Maureen, Cunningham Thomas, Verkouw Karla, Tabtabai Sara, Steiner Johannes, Dec G William, Ausiello Dennis
Center for Laryngeal Surgery and Voice Rehabilitation, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Institute for Heart, Vascular and Stroke Care, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
J Acoust Soc Am. 2017 Oct;142(4):EL401. doi: 10.1121/1.5007092.
This pilot study used acoustic speech analysis to monitor patients with heart failure (HF), which is characterized by increased intracardiac filling pressures and peripheral edema. HF-related edema in the vocal folds and lungs is hypothesized to affect phonation and speech respiration. Acoustic measures of vocal perturbation and speech breathing characteristics were computed from sustained vowels and speech passages recorded daily from ten patients with HF undergoing inpatient diuretic treatment. After treatment, patients displayed a higher proportion of automatically identified creaky voice, increased fundamental frequency, and decreased cepstral peak prominence variation, suggesting that speech biomarkers can be early indicators of HF.
这项试点研究使用声学语音分析来监测心力衰竭（HF）患者，其特征为心内充盈压升高和外周水肿。据推测，声带和肺部与HF相关的水肿会影响发声和言语呼吸。通过对10名正在接受住院利尿治疗的HF患者每天记录的持续元音和言语段落进行计算，得出了嗓音扰动和言语呼吸特征的声学指标。治疗后，患者出现自动识别的粗糙嗓音比例更高、基频增加以及谐波峰值突出度变化减小的情况，这表明言语生物标志物可能是HF的早期指标。
