细胞骨架和细胞的力学性质
Mechanical Properties of the Cytoskeleton and Cells.
机构信息
Department of Physics and School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts 02138.
Institute for Medicine and Engineering and Department of Physiology, Perelman School of Medicine, and Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, Pennsylvania 19104.
出版信息
Cold Spring Harb Perspect Biol. 2017 Nov 1;9(11):a022038. doi: 10.1101/cshperspect.a022038.
Abstract
SUMMARYThe cytoskeleton is the major mechanical structure of the cell; it is a complex, dynamic biopolymer network comprising microtubules, actin, and intermediate filaments. Both the individual filaments and the entire network are not simple elastic solids but are instead highly nonlinear structures. Appreciating the mechanics of biopolymer networks is key to understanding the mechanics of cells. Here, we review the mechanical properties of cytoskeletal polymers and discuss the implications for the behavior of cells.
摘要
摘要细胞骨架是细胞的主要机械结构；它是一个复杂的、动态的生物聚合物网络，由微管、肌动蛋白和中间丝组成。单个纤维和整个网络都不是简单的弹性固体，而是高度非线性的结构。了解生物聚合物网络的力学性质是理解细胞力学的关键。本文综述了细胞骨架聚合物的力学性质，并讨论了其对细胞行为的影响。
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本文引用的文献
1
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Soft Matter. 2016 Jun 14;12(22):5050-60. doi: 10.1039/c6sm00606j. Epub 2016 May 13.
2
Broken detailed balance at mesoscopic scales in active biological systems.活性生物系统中介观尺度下的破缺细致平衡
Science. 2016 Apr 29;352(6285):604-7. doi: 10.1126/science.aac8167.
3
Uncoupling shear and uniaxial elastic moduli of semiflexible biopolymer networks: compression-softening and stretch-stiffening.半柔性生物聚合物网络的剪切与单轴弹性模量解耦：压缩软化与拉伸硬化
Sci Rep. 2016 Jan 13;6:19270. doi: 10.1038/srep19270.
4
Emergent properties of composite semiflexible biopolymer networks.复合半柔性生物聚合物网络的涌现特性。
Bioarchitecture. 2014;4(4-5):138-43. doi: 10.4161/19490992.2014.989035.
5
Atomic force microscopy-based force measurements on animal cells and tissues.基于原子力显微镜的动物细胞和组织力测量
Methods Cell Biol. 2015;125:211-35. doi: 10.1016/bs.mcb.2014.10.005. Epub 2015 Jan 7.
6
Investigating cell mechanics with atomic force microscopy.用原子力显微镜研究细胞力学。
J R Soc Interface. 2015 Mar 6;12(104):20140970. doi: 10.1098/rsif.2014.0970.
7
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