Department of Physics and School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts 02138.
Institute for Medicine and Engineering and Department of Physiology, Perelman School of Medicine, and Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, Pennsylvania 19104.
Cold Spring Harb Perspect Biol. 2017 Nov 1;9(11):a022038. doi: 10.1101/cshperspect.a022038.
SUMMARYThe cytoskeleton is the major mechanical structure of the cell; it is a complex, dynamic biopolymer network comprising microtubules, actin, and intermediate filaments. Both the individual filaments and the entire network are not simple elastic solids but are instead highly nonlinear structures. Appreciating the mechanics of biopolymer networks is key to understanding the mechanics of cells. Here, we review the mechanical properties of cytoskeletal polymers and discuss the implications for the behavior of cells.
摘要细胞骨架是细胞的主要机械结构；它是一个复杂的、动态的生物聚合物网络，由微管、肌动蛋白和中间丝组成。单个纤维和整个网络都不是简单的弹性固体，而是高度非线性的结构。了解生物聚合物网络的力学性质是理解细胞力学的关键。本文综述了细胞骨架聚合物的力学性质，并讨论了其对细胞行为的影响。
