Institute for X-Ray Physics, University of Göttingen, Germany; German Center for Cardiovascular Research (DZHK), Partner Site Göttingen, Germany.
Institute for X-Ray Physics, University of Göttingen, Germany.
Curr Opin Cell Biol. 2023 Dec;85:102263. doi: 10.1016/j.ceb.2023.102263. Epub 2023 Oct 21.
Together with actin filaments and microtubules, intermediate filaments (IFs) constitute the eukaryotic cytoskeleton and each of the three filament types contributes very distinct mechanical properties to this intracellular biopolymer network. IFs assemble hierarchically, rather than polymerizing from nuclei of a small number of monomers or dimers, as is the case with actin filaments and microtubules, respectively. This pathway leads to a molecular architecture specific to IFs and intriguing mechanical and dynamic properties: they are the most flexible cytoskeletal filaments and extremely extensible. Moreover, IFs are very stable against disassembly. Thus, they contribute important properties to cell mechanics, which recently have been investigated with state-of-the-art experimental and computational methods.
与肌动蛋白丝和微管一起，中间丝（IFs）构成了真核细胞骨架，这三种纤维类型中的每一种都为细胞内生物聚合物网络提供了非常独特的机械性能。IF 是按照层次组装的，而不是像肌动蛋白丝和微管那样分别从少数单体或二聚体的核中聚合。这种途径导致了 IF 特有的分子结构和有趣的机械和动态特性：它们是最灵活的细胞骨架纤维，具有极强的伸缩性。此外，IF 非常稳定，不易解体。因此，它们为细胞力学提供了重要的特性，最近已经通过最先进的实验和计算方法进行了研究。
