Kurnit Katherine C, Bailey Ann M, Zeng Jia, Johnson Amber M, Shufean Md Abu, Brusco Lauren, Litzenburger Beate C, Sánchez Nora S, Khotskaya Yekaterina B, Holla Vijaykumar, Simpson Amy, Mills Gordon B, Mendelsohn John, Bernstam Elmer, Shaw Kenna, Meric-Bernstam Funda
Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Sheikh Khalifa Bin Zayed Al Nahyan Institute for Personalized Cancer Therapy, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Cancer Res. 2017 Nov 1;77(21):e123-e126. doi: 10.1158/0008-5472.CAN-17-0341.
High-throughput genomic and molecular profiling of tumors is emerging as an important clinical approach. Molecular profiling is increasingly being used to guide cancer patient care, especially in advanced and incurable cancers. However, navigating the scientific literature to make evidence-based clinical decisions based on molecular profiling results is overwhelming for many oncology clinicians and researchers. The Personalized Cancer Therapy website (www.personalizedcancertherapy.org) was created to provide an online resource for clinicians and researchers to facilitate navigation of available data. Specifically, this resource can be used to help identify potential therapy options for patients harboring oncogenic genomic alterations. Herein, we describe how content on www.personalizedcancertherapy.org is generated and maintained. We end with case scenarios to illustrate the clinical utility of the website. The goal of this publicly available resource is to provide easily accessible information to a broad oncology audience, as this may help ease the information retrieval burden facing participants in the precision oncology field. .
肿瘤的高通量基因组和分子剖析正成为一种重要的临床方法。分子剖析越来越多地被用于指导癌症患者的治疗，尤其是在晚期和无法治愈的癌症中。然而，对于许多肿瘤临床医生和研究人员来说，在科学文献中查找基于分子剖析结果做出循证临床决策的依据是一项艰巨的任务。个性化癌症治疗网站（www.personalizedcancertherapy.org）的创建是为临床医生和研究人员提供一个在线资源，以方便他们浏览现有数据。具体而言，该资源可用于帮助为携带致癌基因组改变的患者确定潜在的治疗方案。在此，我们描述了www.personalizedcancertherapy.org上的内容是如何生成和维护的。我们以案例场景结束，以说明该网站的临床实用性。这个公开可用资源的目标是为广大肿瘤学界提供易于获取的信息，因为这可能有助于减轻精准肿瘤学领域参与者面临的信息检索负担。
