• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

冠状动脉走行模式是 WHHLMI 兔（一种冠状动脉粥样硬化动物模型）冠状动脉粥样硬化进展个体差异的原因之一。

The Coronary Artery Running Pattern is One of the Causes of Individual Differences in the Progression of Coronary Atherosclerosis in WHHLMI Rabbits, an Animal Model for Coronary Atherosclerosis.

机构信息

Division of Comparative Pathophysiology, Kobe University Graduate School of Medicine.

Institute for Experimental Animals, Kobe University Graduate School of Medicine.

出版信息

J Atheroscler Thromb. 2018 May 1;25(5):393-404. doi: 10.5551/jat.41749. Epub 2017 Nov 1.

DOI:10.5551/jat.41749
PMID:29093277
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5945552/
Abstract

AIMS

The relationship between the coronary artery running pattern and development of coronary lesions was re-examined herein using WHHLMI rabbits, an animal model of spontaneous coronary atherosclerosis.

METHODS

The coronary artery running pattern was analyzed using an X-ray computed tomography (CT) apparatus after perfusion. Pathological sections were prepared (Victoria blue-HE staining) at 100 µm intervals from the origin of the left circumflex artery (LCX). The severity of coronary lesions was evaluated based on cross-sectional narrowing (lesion area/inner area of the internal elastic lamina).

RESULTS

In the CT analysis, the angle of the main curvature of the LCX negatively correlated with the percentage of sections with lesions and cross-sectional narrowing. The percentage of sections with lesions was significantly higher in acute angle-type LCX than in obtuse angle-type LCX. Cross-sectional narrowing was also significantly greater in acute angle-type LCX than in obtuse angle-type LCX. The percentage of fibrous lesions was high at the proximal region of LCX, whereas that of lipid-rich lesions was high at the curvature. In 24 months age group, the percentage of sections with calcification in acute angle-type LCX was about twice that in obtuse angle-type LCX.

CONCLUSIONS

Individual differences were observed in the angle of the main curvature of the LCX, which affected the occurrence and extension of atherosclerotic lesions.

摘要

目的

利用自发性冠状动脉粥样硬化 WHHLMI 兔模型，重新研究冠状动脉走行与冠状动脉病变发展之间的关系。

方法

在灌注后使用 X 射线计算机断层扫描（CT）仪分析冠状动脉走行。从左回旋支（LCX）起始处每隔 100μm 制备病理切片（维多利亚蓝-HE 染色）。根据横断面狭窄（病变面积/内弹力膜内面积）评估冠状动脉病变的严重程度。

结果

在 CT 分析中，LCX 的主弯曲角度与病变和横断面狭窄的节段百分比呈负相关。锐角型 LCX 的病变节段百分比明显高于钝角型 LCX。锐角型 LCX 的横断面狭窄也明显大于钝角型 LCX。LCX 近段纤维病变比例较高，而弯曲处富含脂质的病变比例较高。在 24 个月龄组，锐角型 LCX 的钙化节段百分比约为钝角型 LCX 的两倍。

结论

LCX 主弯曲角度存在个体差异，影响动脉粥样硬化病变的发生和进展。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df8c/5945552/a579e6bae046/jat-25-393-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df8c/5945552/03a4c5b0515b/jat-25-393-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df8c/5945552/9f7caa467804/jat-25-393-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df8c/5945552/9b45adae5f3b/jat-25-393-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df8c/5945552/349b9f611fb6/jat-25-393-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df8c/5945552/a32467ac5cc8/jat-25-393-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df8c/5945552/30aaa9d30c2c/jat-25-393-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df8c/5945552/f816f33ca22c/jat-25-393-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df8c/5945552/a579e6bae046/jat-25-393-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df8c/5945552/03a4c5b0515b/jat-25-393-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df8c/5945552/9f7caa467804/jat-25-393-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df8c/5945552/9b45adae5f3b/jat-25-393-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df8c/5945552/349b9f611fb6/jat-25-393-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df8c/5945552/a32467ac5cc8/jat-25-393-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df8c/5945552/30aaa9d30c2c/jat-25-393-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df8c/5945552/f816f33ca22c/jat-25-393-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df8c/5945552/a579e6bae046/jat-25-393-g007.jpg

相似文献

1
The Coronary Artery Running Pattern is One of the Causes of Individual Differences in the Progression of Coronary Atherosclerosis in WHHLMI Rabbits, an Animal Model for Coronary Atherosclerosis.冠状动脉走行模式是 WHHLMI 兔（一种冠状动脉粥样硬化动物模型）冠状动脉粥样硬化进展个体差异的原因之一。
J Atheroscler Thromb. 2018 May 1;25(5):393-404. doi: 10.5551/jat.41749. Epub 2017 Nov 1.
2
Progression of coronary atherosclerosis relates to the onset of myocardial infarction in an animal model of spontaneous myocardial infarction (WHHLMI rabbits).在自发性心肌梗死动物模型（WHHLMI兔）中，冠状动脉粥样硬化的进展与心肌梗死的发生有关。
Exp Anim. 2004 Jul;53(4):339-46. doi: 10.1538/expanim.53.339.
3
Morphological features of coronary plaques in WHHLMI rabbits (Oryctolagus cuniculus), an animal model for familial hypercholesterolemia.WHHLMI兔（穴兔）冠状动脉斑块的形态学特征，家族性高胆固醇血症的动物模型。
Exp Anim. 2017 May 3;66(2):145-157. doi: 10.1538/expanim.16-0078. Epub 2016 Dec 27.
4
Quantitative analyses of lesion areas of coronary atherosclerosis in cholesterol-fed rabbits.高胆固醇喂养兔冠状动脉粥样硬化病变区域的定量分析。
J Vet Med Sci. 1996 Sep;58(9):855-60. doi: 10.1292/jvms.58.855.
5
Identification of novel serum markers for the progression of coronary atherosclerosis in WHHLMI rabbits, an animal model of familial hypercholesterolemia.鉴定 WHHLMI 兔（家族性高胆固醇血症动物模型）冠状动脉粥样硬化进展的新型血清标志物。
Atherosclerosis. 2019 May;284:18-23. doi: 10.1016/j.atherosclerosis.2019.02.020. Epub 2019 Feb 28.
6
Calcification analysis by intravascular ultrasound to define a predictor of left circumflex narrowing after cross-over stenting for unprotected left main bifurcation lesions.通过血管内超声进行钙化分析，以确定无保护左主干分叉病变交叉支架置入术后左旋支狭窄的预测指标。
Cardiovasc Revasc Med. 2014 Mar;15(2):80-5. doi: 10.1016/j.carrev.2014.01.014. Epub 2014 Feb 6.
7
Invasion of atheromatous plaques into tunica media causes coronary outward remodeling in WHHLMI rabbits.动脉粥样硬化斑块侵入中膜导致WHHLMI兔冠状动脉向外重塑。
Atherosclerosis. 2008 Jun;198(2):287-93. doi: 10.1016/j.atherosclerosis.2008.02.010. Epub 2008 Feb 16.
8
Changes in left main bifurcation geometry after a single-stent crossover technique: an intravascular ultrasound study using direct imaging of both the left anterior descending and the left circumflex coronary arteries before and after intervention.左主干分叉病变在单支架对吻技术后的形态变化：介入治疗前后直接显示左前降支和左回旋支的血管内超声研究。
Circ Cardiovasc Interv. 2011 Aug;4(4):355-61. doi: 10.1161/CIRCINTERVENTIONS.110.961045. Epub 2011 Jun 28.
9
Relation between coronary artery geometry and the distribution of early sudanophilic lesions.冠状动脉几何形状与早期嗜苏丹性病变分布之间的关系。
Atherosclerosis. 1993 Jan 25;98(2):193-9. doi: 10.1016/0021-9150(93)90128-h.
10
Distribution of atherosclerotic lesions in various arteries of WHHLMI rabbits, an animal model of familial hypercholesterolemia.载脂蛋白 E 基因缺陷 WHHLMI 兔动脉粥样硬化病变的分布。
Exp Anim. 2019 Aug 14;68(3):293-300. doi: 10.1538/expanim.18-0175. Epub 2019 Mar 1.

引用本文的文献

1
Sex as a Biological Variable in Atherosclerosis.性别作为动脉粥样硬化中的一个生物学变量。
Circ Res. 2020 Apr 24;126(9):1297-1319. doi: 10.1161/CIRCRESAHA.120.315930. Epub 2020 Apr 23.
2
The History of the WHHL Rabbit, an Animal Model of Familial Hypercholesterolemia (I) - Contribution to the Elucidation of the Pathophysiology of Human Hypercholesterolemia and Coronary Heart Disease.载脂蛋白 E 基因缺陷兔模型的建立及其在动脉粥样硬化研究中的应用
J Atheroscler Thromb. 2020 Feb 1;27(2):105-118. doi: 10.5551/jat.RV17038-1. Epub 2019 Nov 21.
3
Distribution of atherosclerotic lesions in various arteries of WHHLMI rabbits, an animal model of familial hypercholesterolemia.

本文引用的文献

1
Incremental Prognostic Value of Coronary Computed Tomography Angiography: High-Risk Plaque Characteristics in Asymptomatic Patients.冠状动脉 CT 血管造影的增量预后价值：无症状患者的高危斑块特征。
J Atheroscler Thromb. 2017 Nov 1;24(11):1174-1185. doi: 10.5551/jat.39115. Epub 2017 Jul 1.
2
Morphological features of coronary plaques in WHHLMI rabbits (Oryctolagus cuniculus), an animal model for familial hypercholesterolemia.WHHLMI兔（穴兔）冠状动脉斑块的形态学特征，家族性高胆固醇血症的动物模型。
Exp Anim. 2017 May 3;66(2):145-157. doi: 10.1538/expanim.16-0078. Epub 2016 Dec 27.
3
Hemodynamics in Coronary Arterial Tree of Serial Stenoses.
载脂蛋白 E 基因缺陷 WHHLMI 兔动脉粥样硬化病变的分布。
Exp Anim. 2019 Aug 14;68(3):293-300. doi: 10.1538/expanim.18-0175. Epub 2019 Mar 1.
串联狭窄冠状动脉树中的血流动力学
PLoS One. 2016 Sep 29;11(9):e0163715. doi: 10.1371/journal.pone.0163715. eCollection 2016.
4
Association of global and local low endothelial shear stress with high-risk plaque using intracoronary 3D optical coherence tomography: Introduction of 'shear stress score'.应用冠状动脉内 3D 光学相干断层成像术评估血管内皮低切应力与高危斑块的相关性：“切应力评分”的提出。
Eur Heart J Cardiovasc Imaging. 2017 May 1;18(8):888-897. doi: 10.1093/ehjci/jew134.
5
Identifying Small Coronary Calcification in Non-Contrast 0.5-mm Slice Reconstruction to Diagnose Coronary Artery Disease in Patients with a Conventional Zero Coronary Artery Calcium Score.在非增强 0.5 毫米层厚重建中识别微小冠状动脉钙化以诊断传统冠状动脉钙化积分零的患者的冠状动脉疾病。
J Atheroscler Thromb. 2016 Dec 1;23(12):1324-1333. doi: 10.5551/jat.35808. Epub 2016 Jul 9.
6
Assessment of Subclinical Atherosclerosis Using Computed Tomography Calcium Scores in Patients with Familial and Nonfamilial Hypercholesterolemia.使用计算机断层扫描钙评分评估家族性和非家族性高胆固醇血症患者的亚临床动脉粥样硬化
J Atheroscler Thromb. 2016 May 2;23(5):588-95. doi: 10.5551/jat.31161. Epub 2015 Dec 14.
7
Clinical implications of the coronary artery calcium score in Japanese patients.日本患者冠状动脉钙化积分的临床意义
J Atheroscler Thromb. 2014;21(11):1101-8. doi: 10.5551/jat.26427. Epub 2014 Sep 26.
8
Vasospasm of atherosclerotic coronary arteries precipitates acute ischemic myocardial damage in myocardial infarction-prone strain of the Watanabe heritable hyperlipidemic rabbits.动脉粥样硬化性冠状动脉痉挛可导致 Watanabe 遗传性高脂血症兔易发生心肌梗死的心肌急性缺血性损伤。
Arterioscler Thromb Vasc Biol. 2013 Nov;33(11):2518-23. doi: 10.1161/ATVBAHA.113.301303. Epub 2013 Aug 29.
9
Biomechanical factors and macrophages in plaque stability.斑块稳定性中的生物力学因素和巨噬细胞。
Cardiovasc Res. 2013 Jul 15;99(2):284-93. doi: 10.1093/cvr/cvt097. Epub 2013 May 17.
10
Localization of culprit lesions in coronary arteries of patients with ST-segment elevation myocardial infarctions: relation to bifurcations and curvatures.罪犯病变在 ST 段抬高型心肌梗死患者冠状动脉中的定位：与分叉和弯曲的关系。
Am Heart J. 2011 Mar;161(3):508-15. doi: 10.1016/j.ahj.2010.11.005. Epub 2011 Jan 15.