Takahashi Hisashi, Kimura Tadashi, Yuki Natsuko, Yoshioka Akira
Department of Neurology, National Hospital Organization Maizuru Medical Center, Japan.
Department of Clinical Research, National Hospital Organization Maizuru Medical Center, Japan.
Intern Med. 2018 Feb 1;57(3):409-412. doi: 10.2169/internalmedicine.8941-17. Epub 2017 Nov 1.
A 79-year-old woman with a history of Guillain-Barré syndrome (GBS) developed somnolence and tetraparesis after pneumonia. Based on clinical and laboratory findings, she was diagnosed with complications of acute inflammatory demyelinating polyneuropathy (AIDP) and acute disseminated encephalomyelitis (ADEM). Anti-galactocerebroside (Gal-C) IgG antibodies were detected in her serum. Cases of recurrent GBS in patients who are positive for this antibody are extremely rare. The anti-Gal-C IgG antibodies likely played an important role in the pathogenesis of the AIDP and ADEM.
一名79岁有吉兰-巴雷综合征(GBS)病史的女性在患肺炎后出现嗜睡和四肢轻瘫。根据临床和实验室检查结果,她被诊断为急性炎症性脱髓鞘性多发性神经病(AIDP)和急性播散性脑脊髓炎(ADEM)并发症。在她的血清中检测到抗半乳糖脑苷脂(Gal-C)IgG抗体。该抗体呈阳性的患者复发性GBS病例极为罕见。抗Gal-C IgG抗体可能在AIDP和ADEM的发病机制中起重要作用。