State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Key Laboratory of Clinical In Vitro Diagnostic Techniques of Zhejiang Province, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310003, China.
Department of Gynecology, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang, 310014, China.
Sci Rep. 2017 Nov 1;7(1):14813. doi: 10.1038/s41598-017-13299-y.
Human papillomavirus infection plays a key role in the development of cervical cancer. To establish a foundation for HPV-based screening and vaccination programs, we investigated the HPV prevalence and genotypic distributions in Chinese women from Zhejiang Province. Between 2011 and 2015, a total of 961,029 samples from 2021 clinical hospitals were tested HPV genotype by a PCR-based hybridization gene chip assay, and 443,890 samples were evaluated cervical cytology by liquid-based cytology analysis. Our results showed that the positive rate for HPV was 20.54%, which ranged from 28.72% to 17.81% and varied by year of recruitment. Age-specific prevalence showed a "two-peak" pattern, with the ≤20-year-old group presenting the highest HPV infection rate, followed by 61-70-year-old group. Overall, the most prevalent genotypes were HPV16, 52 and 58. Additionally, the odds ratios for the prevalence of the HR-HPV, LR-HPV and HPV-negative groups with abnormal cytology were 12.56, 3.21 and 0.06, respectively. Among genotypes, HPV 16 has been found to have the highest OR, followed by HPV58, 18, 52. Here, we present data regarding the prevalence and type distribution of HPV infection, which can serve as valuable reference to guide nationwide cervical cancer screening and HPV vaccination programs.
人乳头瘤病毒（HPV）感染在宫颈癌的发生发展中起着关键作用。为了为 HPV 为基础的筛查和疫苗接种计划奠定基础，我们对来自浙江省的中国女性进行了 HPV 流行率和基因型分布的研究。2011 年至 2015 年期间，采用基于 PCR 的杂交基因芯片检测法对来自 2021 家临床医院的 961029 例样本进行了 HPV 基因型检测，对 443890 例样本进行了液基细胞学分析。结果显示 HPV 阳性率为 20.54%，范围为 28.72%至 17.81%，且呈逐年变化。年龄特异性流行率呈“双峰”模式，≤20 岁年龄组 HPV 感染率最高，其次是 61-70 岁年龄组。总体而言，最常见的基因型是 HPV16、52 和 58。另外，细胞学异常的 HR-HPV、LR-HPV 和 HPV 阴性组的患病率比值比分别为 12.56、3.21 和 0.06。在各基因型中，HPV16 的 OR 最高，其次是 HPV58、18、52。本研究提供了 HPV 感染的流行率和型别分布数据，可作为指导全国宫颈癌筛查和 HPV 疫苗接种计划的有价值参考。
