Research Center for Clinical Virology, Tehran University of Medical Science, Tehran, Iran.
Department of Virology, Faculty of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Virol J. 2024 Sep 20;21(1):227. doi: 10.1186/s12985-024-02496-7.
Human papillomavirus (HPV) is responsible for the most common sexually transmitted infection, particularly among sexually active individuals. Understanding the geographical distribution and epidemiology of the most prevalent HPV genotypes is essential for developing effective prevention strategies. Consequently, this study aimed to examine the distribution of HPV genotypes among HPV-positive women and men in Sari, the capital city of Mazandaran province in northern Iran.
HPV DNA was extracted (PZP Company, Molecular IVD, Iran) from genital and cervical samples of the study participants. Genotyping was conducted for 90 cases utilizing the High + Low Papilloma Strip test (Operon Company, Spain). Demographic data were statistically analyzed in correlation with the virological data (STATA version 17).
Overall, 67.7% (61 out of 90) of the cases tested positive for HPV, with 75% of those being classified as high-risk. The participant group consisted of 92% females (83) and 8% males (7). The highest HPV prevalence, 75% (36), was observed in females and males aged under 31, with the majority of positive cases belonging to high-risk genotypes. The most frequently identified genotypes were HPV-11 (23%), HPV-6 (21%), HPV-56 (18%), HPV-39 (16%), HPV-16, HPV-91, and HPV-66 each comprising (14%). HPV-56 was the most common high-risk genotype, accounting for 11 cases (18%), followed by HPV-39, which was present in 10 cases (16%).
The prevalence of HPV infection was particularly high among individuals under the age of 31 for both genders, with men exhibiting a 100% infection rate. These findings emphasize the urgent need for targeted education aimed at the younger population and the implementation of infection control measures. Specifically, widespread HPV vaccination targeting HPV-6, HPV-11, HPV-39, and HPV-56 should be prioritized for the general population.
人乳头瘤病毒（HPV）是最常见的性传播感染的病原体，尤其在性活跃人群中更为常见。了解最常见 HPV 基因型的地理分布和流行病学特征对于制定有效的预防策略至关重要。因此，本研究旨在探讨伊朗北部马赞达兰省首府萨里 HPV 阳性女性和男性中 HPV 基因型的分布情况。
从研究参与者的生殖器和宫颈样本中提取 HPV DNA（PZP 公司，Molecular IVD，伊朗）。利用 High + Low Papilloma Strip 试验（Operon 公司，西班牙）对 90 例病例进行基因分型。使用 STATA 版本 17 对人口统计学数据与病毒学数据进行统计学分析。
总体而言，90 例病例中 67.7%（61 例）检测出 HPV 阳性，其中 75%为高危型。参与者组包括 92%的女性（83 例）和 8%的男性（7 例）。女性和男性中 HPV 感染率最高的年龄组均为 31 岁以下，占 75%（36 例），大多数阳性病例属于高危基因型。最常识别的基因型是 HPV-11（23%）、HPV-6（21%）、HPV-56（18%）、HPV-39（16%）、HPV-16、HPV-91 和 HPV-66 各占 14%。HPV-56 是最常见的高危型基因型，占 11 例（18%），其次是 HPV-39，占 10 例（16%）。
无论男女，31 岁以下人群 HPV 感染率均较高，男性感染率为 100%。这些发现强调了针对年轻人群进行有针对性教育和实施感染控制措施的迫切需要。具体而言，应优先考虑针对普通人群接种 HPV-6、HPV-11、HPV-39 和 HPV-56 的 HPV 疫苗。
