Department of Gynecology, First Affiliated Hospital of China Medical University, Shenyang, China.
J Med Virol. 2015 Jul;87(7):1248-53. doi: 10.1002/jmv.24029. Epub 2015 Apr 16.
Infection by human papillomavirus (HPV) is a necessary cause of cervical cancer. The purpose of this study was to investigate the prevalence and genotype distribution of HPV infection in Chinese women who were asymptomatic for cervical diseases. Cervical cytology samples were collected from 6479 asymptomatic Chinese women of Liaoning province, and tested for various HPV genotypes using a chip hybridization assay. HPV was found in 10.3% of all the asymptomatic women studied, with the prevalence of high risk HPV (HR HPV) and low risk HPV (LR HPV) being 9.5% and 1.1%, respectively. HPV genotypes 16, 52, and 58 were found the most frequently genotypes in the HR HPV positive women, and were present in 26.2%, 19.4% and 13.8%, respectively. A graph of HR HPV positive infection rates as a function of age is U-shaped, with a peak in women less than 30 years old and a second peak among women older than 50 years. Nearly half of the women infected with either HR HPV or LR HPV presented a normal looking cervix upon visual examination. The current study demonstrates that the epidemiology of HPV infection in asymptomatic Chinese women in Liaoning province is different from that in women from other regions, even from patients with cervical lesions in the same region. These findings could be used to guide the generation and design of an HPV vaccine for this population.
人乳头瘤病毒（HPV）感染是宫颈癌的必要病因。本研究旨在调查辽宁省无症状宫颈疾病女性 HPV 感染的流行率和基因型分布。采集了辽宁省 6479 例无症状女性的宫颈细胞学样本，采用芯片杂交法检测各种 HPV 基因型。所有研究无症状女性中 HPV 的检出率为 10.3%，高危型 HPV（HR HPV）和低危型 HPV（LR HPV）的检出率分别为 9.5%和 1.1%。在 HR HPV 阳性女性中，HPV 基因型 16、52 和 58 最为常见，分别占 26.2%、19.4%和 13.8%。HR HPV 阳性感染率随年龄变化的曲线呈 U 型，30 岁以下和 50 岁以上女性中出现峰值。将近一半的 HR HPV 或 LR HPV 感染者在肉眼检查时宫颈外观正常。本研究表明，辽宁省无症状中国女性 HPV 感染的流行病学与其他地区女性甚至同一地区宫颈病变患者不同。这些发现可用于指导针对该人群的 HPV 疫苗的产生和设计。
