Weber C A, Santiago R M
Department of Medicine, Wilford Hall USAF Medical Center, Lackland AFB, Texas 78236-5300.
Chest. 1989 Jan;95(1):56-9. doi: 10.1378/chest.95.1.56.
Toxic reaction to theophylline compounds is common. Oral activated charcoal (OAC) is a widely accepted mode of therapy for management of moderate to severe cases of theophylline toxicity. Magnesium-containing cathartics are generally recommended in conjunction with OAC in the treatment of drug or toxin ingestions. We report two cases of hypermagnesemia complicating the treatment of theophylline toxicity with OAC and magnesium citrate. In both patients, the hypermagnesemia contributed significantly to morbidity or mortality. In light of these cases and after review of the literature, we suggest that sorbitol be considered the cathartic agent of choice in the treatment of theophylline toxicity with OAC.
对茶碱类化合物的毒性反应很常见。口服活性炭（OAC）是治疗中度至重度茶碱中毒广泛接受的一种治疗方式。在治疗药物或毒素摄入时，通常建议将含镁泻药与OAC联合使用。我们报告了两例在使用OAC和枸橼酸镁治疗茶碱中毒时并发高镁血症的病例。在这两名患者中，高镁血症对发病或死亡有显著影响。鉴于这些病例并经文献复习，我们建议在使用OAC治疗茶碱中毒时，山梨醇应被视为首选的泻药。
