Wojtkowska Izabela, Bonda Tomasz A, Wolszakiewicz Jadwiga, Osak Jerzy, Tysarowski Andrzej, Seliga Katarzyna, Siedlecki Janusz A, Winnicka Maria M, Piotrowicz Ryszard, Stępińska Janina
Institute of Cardiology, Intensive Cardiac Therapy Clinic, Alpejska St. 42, 04-628 Warsaw, Poland.
Department of General and Experimental Pathology, Medical University of Bialystok, Mickiewicza St. 2c, 15-222 Bialystok, Poland.
PPAR Res. 2017;2017:1924907. doi: 10.1155/2017/1924907. Epub 2017 Sep 28.
Activation of PPARs may be involved in the development of heart failure (HF). We evaluated the relationship between expression of PPAR in the myocardium during coronary artery bypass grafting (CABG) and exercise tolerance initially and during follow-up. 6-minute walking test was performed before CABG, after 1, 12, 24 months. Patients were divided into two groups (HF and non-HF) based on left ventricular ejection fraction and plasma proBNP level. After CABG, 67% of patients developed HF. The mean distance 1 month after CABG in HF was 397 ± 85 m versus 420 ± 93 m in non-HF. PPAR mRNA expression was similar in both HF and non-HF groups. 6MWT distance 1 month after CABG was inversely correlated with PPAR level only in HF group. Higher PPAR expression was related to smaller LVEF change between 1 month and 1 year ( = 0.18, < 0.05), especially in patients with HF. Higher initial levels of IL-6 in HF patients were correlated with longer distance in 6MWT one month after surgery and lower PPAR expression. PPAR expression is not related to LVEF before CABG and higher PPAR expression in the myocardium of patients who are developing HF following CABG may have some protecting effect.
过氧化物酶体增殖物激活受体（PPARs）的激活可能与心力衰竭（HF）的发生发展有关。我们评估了冠状动脉旁路移植术（CABG）期间心肌中PPAR的表达与初始及随访期间运动耐量之间的关系。在CABG前、术后1个月、12个月、24个月进行6分钟步行试验。根据左心室射血分数和血浆脑钠肽前体水平将患者分为两组（HF组和非HF组）。CABG后，67%的患者发生HF。HF组CABG后1个月的平均步行距离为397±85米，而非HF组为420±93米。HF组和非HF组的PPAR mRNA表达相似。仅在HF组中，CABG后1个月的6分钟步行试验距离与PPAR水平呈负相关。较高的PPAR表达与1个月至1年期间较小的左心室射血分数变化相关（r = 0.18，P < 0.05），尤其是在HF患者中。HF患者较高的初始白细胞介素-6水平与术后1个月6分钟步行试验中较长的距离和较低的PPAR表达相关。PPAR表达与CABG前的左心室射血分数无关，CABG后发生HF的患者心肌中较高的PPAR表达可能具有一定的保护作用。
