Dos Santos Rosimeire Resende, Nunes Paiva Maria José, Veloso Júlio César, Serp Philippe, Lourdes Cardeal Zenilda de, Menezes Helvécio Costa
Departamento de Química, Universidade Federal de Minas Gerais, Belo Horizonte; Brasil, MG, 31270-901, Brazil.
Departamento de Farmácia, Universidade Federal de São João Del-Rei, Divinópolis, MG, 35501296, Brazil.
Bioanalysis. 2017 Nov;9(21):1655-1666. doi: 10.4155/bio-2017-0140. Epub 2017 Nov 2.
The increasing use of cocaine (COC) during breastfeeding has led to growing concern about exposure of infants. Therefore, to study this exposure, a new method to analyze COC and benzoylecgonine in breast milk was developed.
A new extraction method was used for the first time to analyze COC and its major metabolite, benzoylecgonine, in breast milk using magnetic carbon nanotubes partially doped with nitrogen.
The calibration curves were linear in the range 5.0-180.0 ng ml. The limit of quantification was 5.0 ng ml. Coefficients of variation were between 3.2 and 13.9%. Recovery was between 89.6 and 99.2%.
The proposed method is simple, efficient and suitable to determine analytes in breast milk.
母乳喂养期间可卡因（COC）的使用日益增加，这引发了人们对婴儿接触该物质的日益关注。因此，为研究这种接触情况，开发了一种分析母乳中COC和苯甲酰爱康宁的新方法。
首次采用一种新的提取方法，使用部分掺氮的磁性碳纳米管分析母乳中的COC及其主要代谢物苯甲酰爱康宁。
校准曲线在5.0 - 180.0纳克/毫升范围内呈线性。定量限为5.0纳克/毫升。变异系数在3.2%至13.9%之间。回收率在89.6%至99.2%之间。
所提出的方法简单、高效，适用于测定母乳中的分析物。
