Institute of Sport Sciences and Physiotherapy, Faculty of Medicine, University of Tartu, Tartu, Estonia.
Department of Neuropsychopharmacology, Institute of Psychology, University of Tartu, Tartu, Estonia.
Scand J Med Sci Sports. 2018 Mar;28(3):1084-1091. doi: 10.1111/sms.13002. Epub 2017 Nov 17.
It is unclear whether cardiorespiratory fitness (CRF) remains associated with metabolic risk if controlled for central adiposity and other confounders; thus, the aim of this study was to investigate the independent effect of CRF on metabolic syndrome risk factors in relatively homogeneous age group of young adults. In this cross-sectional study, 828 participants performed CRF test on a cycle ergometer (W ) and were categorized into sex-specific tertiles. Continuous metabolic syndrome risk score (MetS-score) was calculated as the sum of standardized scores of five metabolic syndrome risk factors: glucose, mean arterial pressure, low-density lipoprotein cholesterol, triglycerides, and total cholesterol/high-density lipoprotein cholesterol ratio. Low fitness group had higher values in all measured metabolic syndrome parameters, except for cholesterol parameters, compared to high fitness group. The unadjusted model indicated that CRF was negatively associated with clustered metabolic risk (β = -0.116, P = .001). After the adjustment of smoking habits, sports training participation, and waist circumference, the association between CRF and MetS-score slightly increased (β = -0.126; P < .001). Low CRF was associated with increased risk (OR = 2.58 (95% CI 1.50-4.41)) for higher MetS-score after adjustment for potential confounders and waist circumference. The results of our study indicate that being highly fit increases the likelihood of having lower MetS-score for approximately 2 and 2.5 times independently of central adiposity compared to average and low fitness, respectively. In conclusion, it is highly important to improve CRF through regular exercise, not focusing just on body composition in young adulthood in every weight status group.
目前尚不清楚，如果将中心性肥胖和其他混杂因素控制在内，心肺适能（CRF）是否仍然与代谢风险相关；因此，本研究旨在调查 CRF 对相对同质的年轻成年人代谢综合征危险因素的独立影响。在这项横断面研究中，828 名参与者在功率自行车上进行了 CRF 测试，并按性别分为特定的三分位组。连续代谢综合征风险评分（MetS-score）的计算方法是将五个代谢综合征危险因素的标准化评分相加：血糖、平均动脉压、低密度脂蛋白胆固醇、甘油三酯和总胆固醇/高密度脂蛋白胆固醇比值。与高体能组相比，低体能组在所有测量的代谢综合征参数中，除了胆固醇参数外，所有参数的值都更高。未调整模型表明，CRF 与聚集的代谢风险呈负相关（β=-0.116，P=.001）。在调整了吸烟习惯、运动训练参与和腰围后，CRF 与 MetS-score 之间的关联略有增加（β=-0.126；P<.001）。低 CRF 与较高的 MetS-score 风险增加相关（调整潜在混杂因素和腰围后，OR=2.58（95%CI 1.50-4.41））。与平均和低体能相比，高体能独立于中心性肥胖，使 MetS-score 降低的可能性分别增加了约 2 倍和 2.5 倍。总之，在每个体重状态组中，通过定期运动提高 CRF 非常重要，而不仅仅是关注身体成分。
