Gedvilaite Alma, Tryland Morten, Ulrich Rainer G, Schneider Julia, Kurmauskaite Vaida, Moens Ugo, Preugschas Hannah, Calvignac-Spencer Sébastien, Ehlers Bernhard
Institute of Biotechnology, Vilnius University, Vilnius, Lithuania.
Department of Arctic and Marine Biology, Arctic Infection Biology, UIT-The Arctic University of Norway, Tromsø, Norway.
J Gen Virol. 2017 Dec;98(12):3060-3067. doi: 10.1099/jgv.0.000948.
Shrews (family ) have already been reported to host microorganisms pathogenic for humans. In an effort to search for additional infectious agents with zoonotic potential, we detected polyomaviruses (PyVs) in common shrew, crowned shrew, and pygmy shrew ( and ). From these, 11 full circular genomes were determined. Phylogenetic analysis based on large T protein sequences showed that these novel PyVs form a separate clade within the genus . Within this clade, the phylogenetic relationships suggest host-virus co-divergence. Surprisingly, one PyV from common shrew showed a genomic sequence nearly identical to that of the human polyomavirus 12 (HPyV12). This indicated that HPyV12 is a variant of a non-human PyV that naturally infects shrews. Whether HPyV12 is a bona fide human-tropic polyomavirus arising from a recent shrew-to-human transmission event or instead reflects a technical artefact, such as consumable contamination with shrew material, needs further investigation.
鼩鼱（鼩鼱科）已被报道携带对人类致病的微生物。为了寻找具有人畜共患病潜力的其他传染源，我们在普通鼩鼱、冠鼩鼱和侏儒鼩鼱中检测到了多瘤病毒（PyVs）。从中确定了11个完整的环状基因组。基于大T蛋白序列的系统发育分析表明，这些新型PyVs在该属内形成了一个单独的进化枝。在这个进化枝内，系统发育关系表明宿主与病毒共同分化。令人惊讶的是，一只普通鼩鼱体内的一种PyV显示出与人类多瘤病毒12型（HPyV12）几乎相同的基因组序列。这表明HPyV12是一种自然感染鼩鼱的非人类PyV的变体。HPyV12是最近从鼩鼱传播给人类而产生的真正嗜人多瘤病毒，还是相反反映了一种技术假象，如耗材被鼩鼱材料污染，这需要进一步研究。
