Department of Medical Research, Bærum Hospital, Vestre Viken Hospital Trust, N-3004 Drammen, Norway.
Center for Heart Failure Research, Institute of Clinical Medicine, University of Oslo, N-0407 Oslo, Norway.
Europace. 2018 Nov 1;20(FI_3):f299-f305. doi: 10.1093/europace/eux293.
To investigate the yield of screening for atrial fibrillation (AF) in a cohort of 65-year-old individuals from the general population with additional risk factors for stroke.
We invited participants with additional risk factors for stroke (CHA2DS2-VASc score ≥2 for men or ≥ 3 for women) without previously known AF from a population-based study in Norway to participate in a 2-week screening for AF. Screening was performed by one-lead 'thumb electrocardiography (ECG)' recordings of 30 s twice daily or when the participants experienced symptoms. In total, 1742 (47.0%) participants of the Akershus Cardiac Examination (ACE) 1950 study had at least one additional risk factor for stroke. Of these, 123 cases reported a history of AF and 101 (5.8%) cases were ECG validated. Eight [0.5%, 95% confidence interval (CI) 0.2-0.9] new AF cases were diagnosed by 12-lead ECG at baseline, and 10 additional participants were diagnosed with AF before screening commenced. We invited all 1601 participants who met the inclusion criteria for screening, of which 1510 (94.3%) participants were included (44% women and 56% men). The screening revealed AF in 13 (0.9%, 95% CI 0.5-1.5) participants. The total prevalence of ECG-validated AF after screening among the 65-year-olds with risk factors for stroke was 7.6% (95% CI 6.4-8.9), in men 10.0% (95% CI 8.2-12.0), and in women 4.3% (95% CI 3.0-6.1) (P < 0.001).
In a group of 1510 well-characterized 65-year-olds with risk factors for stroke, 2-week intermittent ECG screening identified undiagnosed AF in 0.9%. The total prevalence of AF was 7.6%.
在一项针对具有中风额外风险因素的 65 岁人群的队列中，研究心房颤动（AF）筛查的检出率。
我们邀请了来自挪威一项基于人群的研究中具有中风额外风险因素（CHA2DS2-VASc 评分男性≥2 分或女性≥3 分）且无已知 AF 病史的参与者参加为期 2 周的 AF 筛查。筛查通过每日两次进行 30 秒的单导联“拇指心电图（ECG）”记录或当参与者出现症状时进行。共有 1742 名（47.0%）Akershus 心脏检查（ACE）1950 研究的参与者具有中风的至少一项额外风险因素。其中，123 例报告有 AF 病史，101 例（5.8%）经 ECG 证实。在基线时通过 12 导联 ECG 诊断出 8 例[0.5%，95%置信区间（CI）0.2-0.9]新的 AF 病例，在筛查开始前有 10 名参与者被诊断为 AF。我们邀请了所有符合筛查条件的 1601 名参与者，其中 1510 名（94.3%）参与者符合入选标准（44%为女性，56%为男性）。筛查发现 13 名（0.9%，95%CI 0.5-1.5）参与者存在 AF。在具有中风风险因素的 65 岁人群中，经筛查后 ECG 证实的 AF 总患病率为 7.6%（95%CI 6.4-8.9），男性为 10.0%（95%CI 8.2-12.0），女性为 4.3%（95%CI 3.0-6.1）（P<0.001）。
在 1510 名具有中风风险因素的特征明确的 65 岁人群中，为期 2 周的间歇性 ECG 筛查发现了 0.9%的未确诊 AF。AF 的总患病率为 7.6%。
