胸腺在对自身蛋白抗原的天然耐受性中的作用。
Role of the thymus in natural tolerance to an autologous protein antigen.
作者信息
Boguniewicz M, Sunshine G H, Borel Y
机构信息
Division of Immunology, Children's Hospital, Boston, Massachusetts.
出版信息
J Exp Med. 1989 Jan 1;169(1):285-90. doi: 10.1084/jem.169.1.285.
Abstract
C5-deficient mice grafted with thymus from C5-sufficient donors and immunized with C5 failed to make humoral antibody to C5, suggesting that the transfer of thymus had induced tolerance. Irradiated C5-deficient hosts repopulated with lymphoid cells from thymectomized C5-deficient mice grafted with C5-sufficient thymus also failed to respond to immunization with C5, thus showing that the state of tolerance can be adoptively transferred. These results demonstrate that natural tolerance to self-protein antigen is "learned" in the thymus.
摘要
将来自C5充足供体的胸腺移植到C5缺陷小鼠体内，并对其进行C5免疫，这些小鼠未能产生针对C5的体液抗体，这表明胸腺移植诱导了耐受性。用来自移植了C5充足胸腺的胸腺切除的C5缺陷小鼠的淋巴细胞重新填充的受辐照C5缺陷宿主，对C5免疫也没有反应，从而表明耐受性状态可以被过继转移。这些结果证明，对自身蛋白抗原的天然耐受性是在胸腺中“习得”的。
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Immunology. 1991 Nov;74(3):380-5.
本文引用的文献
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Tolerance of thymic cytotoxic T lymphocytes to allogeneic H-2 determinants encountered prethymically: evidence for expression of anti-H-2 receptors prior to entry into the thymus.胸腺细胞毒性T淋巴细胞对胸腺前遇到的同种异体H-2决定簇的耐受性：进入胸腺之前抗H-2受体表达的证据。
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Human monocyte spreading induced by factor Bb of the alternative pathway of complement activation. A possible role for C5 in monocyte spreading.补体激活替代途径的B因子诱导人单核细胞铺展。C5在单核细胞铺展中的可能作用。
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A natural model of immunologic tolerance. Tolerance to murine C5 is mediated by T cells, and antigen is required to maintain unresponsiveness.一种免疫耐受的天然模型。对小鼠C5的耐受由T细胞介导，且需要抗原以维持无反应性。
J Exp Med. 1982 Aug 1;156(2):567-84. doi: 10.1084/jem.156.2.567.
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