胸腺中MHC限制特异性及耐受性的诱导。 - Suppr

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超能文献

Induction of MHC-restricted specificity and tolerance in the thymus.

作者信息

Lo D, Ron Y, Sprent J

出版信息

Immunol Res. 1986;5(3):221-32. doi: 10.1007/BF02919203.

DOI:10.1007/BF02919203

PMID:3553374

Abstract

摘要

相似文献

Induction of MHC-restricted specificity and tolerance in the thymus.胸腺中MHC限制特异性及耐受性的诱导。

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Immune responses of thymus/lymphocyte embryonic chimeras: studies on tolerance and major histocompatibility complex restriction in Xenopus.胸腺/淋巴细胞胚胎嵌合体的免疫反应：非洲爪蟾中耐受性和主要组织相容性复合体限制的研究

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T-cell tolerance by dendritic cells and macrophages as a mechanism for the major histocompatibility complex-linked resistance to autoimmune diabetes.树突状细胞和巨噬细胞介导的T细胞耐受性作为主要组织相容性复合体相关的自身免疫性糖尿病抗性机制。

Diabetes. 2002 Feb;51(2):325-38. doi: 10.2337/diabetes.51.2.325.

T cell selection in the thymus.胸腺中的T细胞选择。

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Intrathymic tolerance induction: determination of tolerance to class II major histocompatibility complex antigens in maturing T lymphocytes by a bone marrow-derived non-lymphoid thymus cell.胸腺内耐受诱导：骨髓来源的非淋巴细胞性胸腺细胞对成熟T淋巴细胞中II类主要组织相容性复合体抗原耐受性的测定

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MHC restriction, self-tolerance and the thymus.

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Identity of cells that imprint H-2-restricted T-cell specificity in the thymus.在胸腺中赋予H-2限制性T细胞特异性的细胞的身份。

Nature. 1986;319(6055):672-5. doi: 10.1038/319672a0.

Role of reentry of in vivo alloMHC peptide-activated T cells into the adult thymus in acquired systemic tolerance.体内同种异体MHC肽激活的T细胞再进入成年胸腺在获得性全身耐受中的作用。

Transplantation. 2001 Nov 15;72(9):1533-41. doi: 10.1097/00007890-200111150-00011.

The effect of thymus environment on T cell development and tolerance.胸腺环境对T细胞发育及耐受性的影响。

Cell. 1988 May 20;53(4):627-34. doi: 10.1016/0092-8674(88)90578-8.

Homologies between cell interaction molecules controlled by major histocompatibility complex- and Igh-V-linked genes that T cells use for communication; both molecules undergo "adaptive" differentiation in the thymus.主要组织相容性复合体和免疫球蛋白重链可变区（Igh-V）连锁基因所控制的、T细胞用于通讯的细胞相互作用分子之间的同源性；这两种分子在胸腺中都经历“适应性”分化。

Eur J Immunol. 1983 Apr;13(4):285-91. doi: 10.1002/eji.1830130404.

引用本文的文献

Affinity threshold for thymic selection through a T-cell receptor-co-receptor zipper.通过T细胞受体 - 共受体拉链进行胸腺选择的亲和力阈值。

Nat Rev Immunol. 2009 Mar;9(3):207-13. doi: 10.1038/nri2469.

Immune regulation: susceptibility and resistance to autoimmunity.免疫调节：自身免疫的易感性与抗性

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T cell positive selection by a high density, low affinity ligand.通过高密度、低亲和力配体进行T细胞阳性选择。

Proc Natl Acad Sci U S A. 1998 Apr 14;95(8):4522-6. doi: 10.1073/pnas.95.8.4522.

Selection of antigen-specific T cells by a single IEk peptide combination.通过单一的IEk肽组合选择抗原特异性T细胞。

J Exp Med. 1997 Nov 3;186(9):1441-50. doi: 10.1084/jem.186.9.1441.

Thymic stromal cell specialization and the T-cell receptor repertoire.胸腺基质细胞特化与T细胞受体库

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Thymocytes can become mature T cells without passing through the CD4+ CD8+, double-positive stage.胸腺细胞可不经过CD4+CD8+双阳性阶段而发育为成熟的T细胞。

J Exp Med. 1996 Nov 1;184(5):1619-30. doi: 10.1084/jem.184.5.1619.

B cells are not essential for peripheral T-cell tolerance.B细胞对于外周T细胞耐受性并非必不可少。

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Fibroblasts can induce thymocyte positive selection in vivo.成纤维细胞可在体内诱导胸腺细胞阳性选择。

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The use of mammary tumor virus (Mtv)-negative and single-Mtv mice to evaluate the effects of endogenous viral superantigens on the T cell repertoire.利用乳腺肿瘤病毒（Mtv）阴性和单Mtv小鼠评估内源性病毒超抗原对T细胞库的影响。

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T cell receptor-mediated signaling events in CD4+CD8+ thymocytes undergoing thymic selection: requirement of calcineurin activation for thymic positive selection but not negative selection.在经历胸腺选择的CD4+CD8+胸腺细胞中T细胞受体介导的信号事件：钙调神经磷酸酶激活对胸腺阳性选择而非阴性选择的需求。

J Exp Med. 1995 Mar 1;181(3):927-41. doi: 10.1084/jem.181.3.927.

本文引用的文献

Bone marrow origin of Ia-positive cells in the medulla rat thymus.大鼠胸腺髓质中Ia阳性细胞的骨髓起源。

J Exp Med. 1981 Jun 1;153(6):1666-71. doi: 10.1084/jem.153.6.1666.

T-cell specificity for H-2 and Ir gene phenotype correlates with the phenotype of thymic antigen-presenting cells.T细胞对H-2和Ir基因表型的特异性与胸腺抗原呈递细胞的表型相关。

Nature. 1980 Sep 4;287(5777):44-6. doi: 10.1038/287044a0.

Successful transplantation across major histocompatibility barrier of deoxyguanosine-treated embryonic thymus expressing class II antigens.经脱氧鸟苷处理的表达II类抗原的胚胎胸腺跨越主要组织相容性屏障的成功移植。

Nature. 1984;310(5974):231-3. doi: 10.1038/310231a0.

Intrathymic presentation of circulating non-major histocompatibility complex antigens.循环中非主要组织相容性复合体抗原的胸腺内呈递。

Nature. 1984;308(5955):196-9. doi: 10.1038/308196a0.

Role of the H-2 complex in the induction of T cell tolerance to self minor histocompatibility antigens.H-2复合体在诱导T细胞对自身次要组织相容性抗原产生耐受性中的作用。

J Exp Med. 1983 Nov 1;158(5):1483-97. doi: 10.1084/jem.158.5.1483.

Functional clonal deletion of cytotoxic T-lymphocyte precursors in chimeric thymus produced in vitro from embryonic Anlagen.在由胚胎原基体外产生的嵌合胸腺中，细胞毒性T淋巴细胞前体的功能性克隆缺失。

Proc Natl Acad Sci U S A. 1983 May;80(10):3045-9. doi: 10.1073/pnas.80.10.3045.

Early appearance of donor-type antigen-presenting cells in the thymuses of 1200 R radiation-induced bone marrow chimeras correlates with self-recognition of donor I region gene products.1200R辐射诱导的骨髓嵌合体胸腺中供体型抗原呈递细胞的早期出现与供体I区基因产物的自身识别相关。

J Immunol. 1983 Jun;130(6):2525-7.

Reduced expression of Ia antigens by thymic epithelial cells of aged mice.老年小鼠胸腺上皮细胞Ia抗原表达降低。

J Immunol. 1984 Jul;133(1):98-103.

Thymocytes appear to ignore class I major histocompatibility complex antigens expressed on thymus epithelial cells.胸腺细胞似乎会忽略胸腺上皮细胞上表达的I类主要组织相容性复合体抗原。

Eur J Immunol. 1984 Nov;14(11):1048-52. doi: 10.1002/eji.1830141116.

Cytotoxic T lymphocyte responses in allogeneic radiation bone marrow chimeras. The chimeric host strictly dictates the self-repertoire of Ia-restricted T cells but not H-2K/D-restricted T cells.同种异体辐射骨髓嵌合体中的细胞毒性T淋巴细胞反应。嵌合宿主严格决定Ia限制性T细胞的自身 repertoire，但不决定H-2K/D限制性T细胞的自身 repertoire。

J Exp Med. 1982 Dec 1;156(6):1650-64. doi: 10.1084/jem.156.6.1650.

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