Egger J, Carter C M, Soothill J F, Wilson J
Department of Neurology, Hospital for Sick Children, London.
J Pediatr. 1989 Jan;114(1):51-8. doi: 10.1016/s0022-3476(89)80600-6.
We studied the role of oligoantigenic diets in 63 children with epilepsy; 45 children had epilepsy with migraine, hyperkinetic behavior, or both, and 18 had epilepsy alone. Of the 45 children who had epilepsy with recurrent headaches, abdominal symptoms, or hyperkinetic behavior, 25 ceased to have seizures and 11 had fewer seizures during diet therapy. Headaches, abdominal pains, and hyperkinetic behavior ceased in all those whose seizures ceased, and in some of those whose seizures did not cease. Foods provoking symptoms were identified by systematic reintroduction of foods, one by one; symptoms recurred with 42 foods, and seizures recurred with 31; most children reacted to several foods. Of 24 children with generalized epilepsy, 18 recovered or improved (including 4 of 7 with myoclonic seizures and all with petit mal), as did 18 of 21 children with partial epilepsy. In double-blind, placebo-controlled provocation studies, symptoms recurred in 15 of 16 children, including seizures in eight; none recurred when placebo was given. Eighteen other children, who had epilepsy alone, were similarly treated with an oligoantigenic diet; none improved.
我们研究了低抗原饮食在63例癫痫患儿中的作用；45例患儿患有癫痫并伴有偏头痛、多动行为或两者兼有，18例仅患有癫痫。在45例患有癫痫且伴有反复头痛、腹部症状或多动行为的患儿中，25例在饮食治疗期间停止发作，11例发作次数减少。所有发作停止的患儿头痛、腹痛和多动行为均消失，部分发作未停止的患儿上述症状也有所缓解。通过逐一系统性重新引入食物来确定引发症状的食物；42种食物引发了症状复发，31种食物引发了癫痫发作复发；大多数患儿对多种食物有反应。24例全身性癫痫患儿中，18例康复或病情改善（包括7例肌阵挛性癫痫患儿中的4例以及所有失神发作患儿），21例部分性癫痫患儿中有18例情况相同。在双盲、安慰剂对照激发试验中，16例患儿中有15例症状复发，其中8例癫痫发作复发；给予安慰剂时无复发情况。另外18例仅患有癫痫的患儿同样接受了低抗原饮食治疗；无人病情改善。
