Department of Immunology and Allergy, Mofid Children Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Pediatrics, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran.
Sci Rep. 2019 May 3;9(1):6875. doi: 10.1038/s41598-019-43252-0.
Recent data has suggested a definitive role for inflammatory processes in the pathophysiology of epilepsy. In this study we hypothesized that food allergies, as chronic inflammatory processes, underlie the pathophysiology of refractory idiopathic epilepsy and investigated whether food elimination diets may assist in managing refractory epilepsy. The study was conducted on 34 patients up to 16 years of age with refractory convulsions who attended the Allergy Outpatient Clinic, Mofid Children Hospital between 2015 and 2016 with youngest and oldest participants at ages of 3 months and 16 years old, respectively. The participants were categorized into three groups according to the results of skin prick test and serum specific IgE measurements. Elimination diets were instituted for the patients with non IgE-mediated and mixed food allergies. The study was conducted for a period of 12 weeks. The participants were assessed for at least 50% reduction in number of seizures following the intervention. There was a significant reduction in number of seizures (p < 0.001) following the intervention. Seventeen patients (50%) did not experience any seizures after 8 weeks of treatment and 12 patients (35%) had a significant (51-99%) decrease in the number of their seizures. Five patients did not show any changes in their daily seizure frequency. The obtained data suggest that food allergy may play a role in triggering refractory epilepsies and their adequate response to treatment. A trial of elimination diet showed more than 50% seizure reduction in more than 85% of the children studied. However, we believe these results are preliminary and they motivate a fully controlled study in the future.
最近的数据表明，炎症过程在癫痫的病理生理学中起着明确的作用。在这项研究中，我们假设食物过敏作为慢性炎症过程，是难治性特发性癫痫的病理生理学基础，并研究了食物消除饮食是否有助于治疗难治性癫痫。该研究于 2015 年至 2016 年在莫菲德儿童医院过敏门诊对 34 名年龄在 16 岁以下的难治性惊厥患者进行，年龄最小和最大的参与者分别为 3 个月和 16 岁。根据皮肤点刺试验和血清特异性 IgE 测量结果，将参与者分为三组。对非 IgE 介导和混合食物过敏的患者进行消除饮食。研究进行了 12 周。对患者进行评估，以确定干预后发作次数减少至少 50%。干预后发作次数明显减少（p < 0.001）。17 名患者（50%）在治疗 8 周后无任何发作，12 名患者（35%）发作次数显著减少（51-99%）。5 名患者每日发作频率无变化。所得数据表明，食物过敏可能在触发难治性癫痫及其对治疗的适当反应中起作用。消除饮食试验显示，超过 85%的研究儿童的发作减少超过 50%。然而，我们认为这些结果是初步的，它们促使我们在未来进行全面的对照研究。
