胃饥饿素作为一种生存激素。
Ghrelin as a Survival Hormone.
作者信息
Mani Bharath K, Zigman Jeffrey M
机构信息
Divisions of Hypothalamic Research and Endocrinology, Department of Internal Medicine, and Department of Psychiatry, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390-9077, USA.
Divisions of Hypothalamic Research and Endocrinology, Department of Internal Medicine, and Department of Psychiatry, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390-9077, USA.
出版信息
Trends Endocrinol Metab. 2017 Dec;28(12):843-854. doi: 10.1016/j.tem.2017.10.001. Epub 2017 Oct 30.
Abstract
Ghrelin administration induces food intake and body weight gain. Based on these actions, the ghrelin system was initially proposed as an antiobesity target. Subsequent studies using genetic mouse models have raised doubts about the role of the endogenous ghrelin system in mediating body weight homeostasis or obesity. However, this is not to say that the endogenous ghrelin system is not important metabolically or otherwise. Here we review an emerging concept in which the endogenous ghrelin system serves an essential function during extreme nutritional and psychological challenges to defend blood glucose, protect body weight, avoid exaggerated depression, and ultimately allow survival.
摘要
施用胃饥饿素会导致食物摄入量增加和体重增加。基于这些作用，胃饥饿素系统最初被提议作为抗肥胖靶点。随后使用基因小鼠模型进行的研究对内源性胃饥饿素系统在介导体重稳态或肥胖中的作用提出了质疑。然而，这并不是说内源性胃饥饿素系统在代谢或其他方面不重要。在此，我们综述了一个新出现的概念，即内源性胃饥饿素系统在极端营养和心理挑战期间发挥着重要作用，以维持血糖水平、保护体重、避免过度抑郁，并最终确保生存。
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Mol Metab. 2017 Jun 22;6(8):882-896. doi: 10.1016/j.molmet.2017.06.011. eCollection 2017 Aug.
2
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Int J Obes (Lond). 2017 Sep;41(9):1413-1419. doi: 10.1038/ijo.2017.123. Epub 2017 May 22.
3
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