CTP合酶在人肝细胞癌中形成细胞蛇。

CTP synthase forms the cytoophidium in human hepatocellular carcinoma.

作者信息

Chang Chia-Chun, Jeng Yung-Ming, Peng Min, Keppeke Gerson Dierley, Sung Li-Ying, Liu Ji-Long

机构信息

Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3PT, United Kingdom; Institute of Biotechnology, National Taiwan University, Taipei 106, Taiwan, Republic of China.

Department of Pathology, National Taiwan University Hospital, Taipei 10002, Taiwan, Republic of China; Graduate Institute of Pathology, National Taiwan University College of Medicine, Taipei 10051, Taiwan, Republic of China.

出版信息

Exp Cell Res. 2017 Dec 15;361(2):292-299. doi: 10.1016/j.yexcr.2017.10.030. Epub 2017 Oct 31.

DOI:10.1016/j.yexcr.2017.10.030

PMID:29097181

Abstract

CTP synthase (CTPS) can aggregate into an intracellular macrostructure, the cytoophidium, in various organisms including human cells. Previous studies have shown that assembly of human CTPS cytoophidia may be correlated with the cellular metabolic status, and is able to promote the activity of CTPS. A correlation between the cytoophidium and cancer metabolism has been proposed but not yet been revealed. In the current study we provide clear evidence of the presence of CTPS cytoophidia in various human cancers and some non-cancerous tissues. Moreover, among 203 tissue samples of hepatocellular carcinoma, 56 (28%) samples exhibited many cytoophidia, whereas no cytoophidia were detected in adjacent non-cancerous hepatocytes for all samples. Our findings suggest that the CTPS cytoophidium may participate in the adaptive metabolism of human hepatocellular carcinoma.

摘要

胞苷三磷酸合成酶（CTPS）可在包括人类细胞在内的多种生物体中聚集成一种细胞内宏观结构——细胞蛇。先前的研究表明，人类CTPS细胞蛇的组装可能与细胞代谢状态相关，并能够促进CTPS的活性。虽然有人提出细胞蛇与癌症代谢之间存在关联，但尚未得到证实。在本研究中，我们提供了明确的证据，证明CTPS细胞蛇存在于各种人类癌症和一些非癌组织中。此外，在203份肝细胞癌组织样本中，有56份（28%）样本表现出许多细胞蛇，而所有样本的相邻非癌肝细胞中均未检测到细胞蛇。我们的研究结果表明，CTPS细胞蛇可能参与人类肝细胞癌的适应性代谢。