Timmins Meghan, Ashlock Daniel
Department of Mathematics and Statistics, University of Guelph, Guelph, Ontario, Canada N1G 2W1.
Biosystems. 2017 Dec;162:205-214. doi: 10.1016/j.biosystems.2017.10.013. Epub 2017 Oct 31.
Graphs can be used as contact networks in models of epidemic spread. Most research seeks to extract the properties of an extant graph, derived from questionnaires or other sources of contact information. The inverse problem of searching the space of graphs for those that exhibit specific properties has received little attention and that is the focus of this study. This is, in part, because searching the space of contact networks is difficult. This paper extends and tests a representation for searching the space of contact networks with evolutionary computation. The focus of this study is on improvements in the representation used to evolve potential contact networks, adding an operator that permits strictly local adjustments to connectivity of the network, and another that does nothing at all. The benefits of doing nothing at some points during the construction of a network are substantial, because this permits evolution to adjust the number of active commands issued automatically. Adjusting local connectivity was identified as a beneficial feature in earlier research. The network induction method is tested on two tasks; finding a network that sustains an epidemic as long as possible and finding a network that, under simulation, closely matches a specified pattern of rise and fall in the number of infections.
在流行病传播模型中,图表可被用作接触网络。大多数研究试图提取现存图表的属性,这些属性源自问卷调查或其他接触信息来源。在图表空间中搜索具有特定属性的图表这一逆问题很少受到关注,而这正是本研究的重点。部分原因在于搜索接触网络空间很困难。本文扩展并测试了一种用于通过进化计算搜索接触网络空间的表示方法。本研究的重点在于改进用于演化潜在接触网络的表示方法,添加一个允许对网络连通性进行严格局部调整的算子,以及另一个完全不做任何操作的算子。在网络构建过程中的某些点不做任何操作的好处是巨大的,因为这允许进化自动调整发出的活动命令数量。在早期研究中,调整局部连通性被认为是一个有益的特征。网络归纳方法在两项任务上进行了测试:找到一个能使流行病持续时间尽可能长的网络,以及找到一个在模拟中与感染数量的指定增减模式紧密匹配的网络。