Liu Lijun, Zhang Liang, Guo Lei, Yu Qing, Li Hong, Teng Jijun, Xie Anmu
Department of Neurology, Affiliated Hospital of Qingdao University, Qingdao, China, China.
Department of Urology, Affiliated Hospital of Qingdao University, Qingdao, China, China.
Neurosci Lett. 2018 Jan 1;662:339-345. doi: 10.1016/j.neulet.2017.10.060. Epub 2017 Oct 31.
The 5,10-methylenetetrahydrofolate reductase (MTHFR) gene has been reported to be a candidate gene for susceptibility to Parkinson's disease (PD), but results of different studies are conflicting. Here, we conducted a meta-analysis of published case-control studies to evaluate the association between MTHFR C677T and A1298C gene polymorphisms with the risk of PD. Electronic search through PubMed, EmBase, ScienceDirect and Cochrane Library was conducted to identify all relevant studies. A total of 19 studies with 2746 cases and 8967 controls were included. No significant association between MTHFR C677T polymorphism and PD risk was found in the overall population in all five genetic models. In the subgroup analysis stratified by ethnicity, a significant association between MTHFR C677T and PD risk was observed in the dominant model in Caucasians (OR=1.175, 95%CI: 1.008-1.369, P=0.040), but not in Asians. Significant association was found between MTHFR A1298C polymorphism and PD risk in the overall population in the dominant (OR=1.168, 95%CI: 1.008-1.353, P=0.039) and heterozygous model (OR=1.172, 95%CI: 1.004-1.367, P=0.044). But in the subgroup analysis, no association was found between MTHFR A1298C and PD neither in Caucasians nor in Asians. Our meta-analysis suggests that MTHFR C677T polymorphism may be associated with increased PD risk in Caucasians and MTHFR A1298C polymorphism may also increase susceptibility to PD.
据报道，5,10-亚甲基四氢叶酸还原酶（MTHFR）基因是帕金森病（PD）易感性的候选基因，但不同研究的结果相互矛盾。在此，我们对已发表的病例对照研究进行了荟萃分析，以评估MTHFR C677T和A1298C基因多态性与PD风险之间的关联。通过PubMed、EmBase、ScienceDirect和Cochrane图书馆进行电子检索，以识别所有相关研究。共纳入19项研究，包括2746例病例和8967例对照。在所有五种遗传模型中，总体人群中未发现MTHFR C677T多态性与PD风险之间存在显著关联。在按种族分层的亚组分析中，在白种人的显性模型中观察到MTHFR C677T与PD风险之间存在显著关联（OR=1.175，95%CI：1.008-1.369，P=0.040），但在亚洲人中未观察到。在总体人群的显性模型（OR=1.168，95%CI：1.008-1.353，P=0.039）和杂合子模型（OR=1.172，95%CI：1.004-1.367，P=0.044）中，发现MTHFR A1298C多态性与PD风险之间存在显著关联。但在亚组分析中，在白种人和亚洲人中均未发现MTHFR A1298C与PD之间存在关联。我们的荟萃分析表明，MTHFR C677T多态性可能与白种人PD风险增加有关，MTHFR A1298C多态性也可能增加PD易感性。
