From the Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Denmark (A.V.); The Copenhagen General Population Study (A.V., B.G.N.) and Department of Clinical Biochemistry, Herlev and Gentofte Hospital (A.V., B.G.N.), Copenhagen University Hospital, Denmark; Faculty of Health and Medical Sciences, University of Copenhagen, Denmark (B.G.N.); and The Copenhagen City Heart Study, Frederiksberg Hospital, Copenhagen University Hospital, Denmark (B.G.N.).
Arterioscler Thromb Vasc Biol. 2018 Feb;38(2):464-472. doi: 10.1161/ATVBAHA.117.310269. Epub 2017 Nov 2.
The prevalence of heart failure is increasing in the aging population, and heart failure is a disease with large morbidity and mortality. There is, therefore, a need for identifying modifiable risk factors for prevention. We tested the hypothesis that high concentrations of nonfasting triglycerides and low-density lipoprotein cholesterol are associated with higher risk of heart failure in the general population.
We included 103 860 individuals from the Copenhagen General Population Study and 9694 from the Copenhagen City Heart Study in 2 prospective observational association studies. Nonfasting triglycerides and low-density lipoprotein cholesterol were measured at baseline. Individuals were followed for ≤23 years, during which time 3593 were diagnosed with heart failure. Hazard ratios were estimated using Cox proportional hazard regression models. In the Copenhagen General Population Study, stepwise higher concentrations of nonfasting triglycerides were associated with stepwise higher risk of heart failure ( for trend <0.001), with a multivariable adjusted hazard ratio of 2.59 (95% confidence interval, 1.48-4.54) for individuals with nonfasting triglycerides ≥5 mmol/L (440 mg/dL) compared with individuals with concentrations <1 mmol/L (88 mg/dL). Concentrations of low-density lipoprotein cholesterol were not associated with risk of heart failure. Results were independently confirmed in the Copenhagen City Heart Study.
Stepwise higher concentrations of nonfasting triglycerides were associated with stepwise higher risk of heart failure; however, concentrations of low-density lipoprotein cholesterol were not associated with risk of heart failure in the general population.
随着人口老龄化，心力衰竭的患病率正在增加，心力衰竭是一种发病率和死亡率都很高的疾病。因此，有必要确定可改变的危险因素以进行预防。我们检验了这样一个假设，即非空腹甘油三酯和低密度脂蛋白胆固醇浓度升高与普通人群中心力衰竭风险增加相关。
我们纳入了两项前瞻性观察性关联研究中的 103860 名哥本哈根普通人群研究参与者和 9694 名哥本哈根城市心脏研究参与者。在基线时测量了非空腹甘油三酯和低密度脂蛋白胆固醇的浓度。对参与者进行了最长 23 年的随访，在此期间有 3593 人被诊断为心力衰竭。使用 Cox 比例风险回归模型估计了风险比。在哥本哈根普通人群研究中，非空腹甘油三酯浓度逐步升高与心力衰竭风险逐步升高相关（趋势检验<0.001），非空腹甘油三酯浓度≥5mmol/L（440mg/dL）的个体与浓度<1mmol/L（88mg/dL）的个体相比，校正多变量后的风险比为 2.59（95%置信区间，1.48-4.54）。低密度脂蛋白胆固醇浓度与心力衰竭风险无关。结果在哥本哈根城市心脏研究中得到独立证实。
非空腹甘油三酯浓度逐步升高与心力衰竭风险逐步升高相关；然而，在普通人群中，低密度脂蛋白胆固醇浓度与心力衰竭风险无关。
