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本文引用的文献

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Australia's notifiable disease status, 2014: Annual report of the National Notifiable Diseases Surveillance System.《2014年澳大利亚法定传染病状况：国家法定传染病监测系统年度报告》
Commun Dis Intell Q Rep. 2016 Mar 31;40(1):E48-145.
2
Mutation at embB codon 306, a potential marker for the identification of multidrug resistance associated with ethambutol in Mycobacterium tuberculosis.embB基因306密码子处的突变，这是一种用于鉴定与结核分枝杆菌中乙胺丁醇相关的多药耐药性的潜在标志物。
Antimicrob Agents Chemother. 2015 Sep;59(9):5455-62. doi: 10.1128/AAC.00117-15. Epub 2015 Jun 29.
3
Rapid determination of anti-tuberculosis drug resistance from whole-genome sequences.通过全基因组序列快速测定抗结核药物耐药性。
Genome Med. 2015 May 27;7(1):51. doi: 10.1186/s13073-015-0164-0. eCollection 2015.
4
Four decades of transmission of a multidrug-resistant Mycobacterium tuberculosis outbreak strain.耐多药结核分枝杆菌暴发菌株四十年来的传播情况
Nat Commun. 2015 May 11;6:7119. doi: 10.1038/ncomms8119.
5
PhyResSE: a Web Tool Delineating Mycobacterium tuberculosis Antibiotic Resistance and Lineage from Whole-Genome Sequencing Data.PhyResSE：一种从全基因组测序数据中描绘结核分枝杆菌抗生素耐药性和谱系的网络工具。
J Clin Microbiol. 2015 Jun;53(6):1908-14. doi: 10.1128/JCM.00025-15. Epub 2015 Apr 8.
6
Mycobacterium tuberculosis pyrazinamide resistance determinants: a multicenter study.结核分枝杆菌吡嗪酰胺耐药决定因素：一项多中心研究。
mBio. 2014 Oct 21;5(5):e01819-14. doi: 10.1128/mBio.01819-14.
7
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8
Draft Genome Sequence of the First Isolate of Extensively Drug-Resistant Mycobacterium tuberculosis in Ireland.爱尔兰首例广泛耐药结核分枝杆菌分离株的基因组序列草图
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9
Rapid diagnosis of pyrazinamide-resistant multidrug-resistant tuberculosis using a molecular-based diagnostic algorithm.采用基于分子的诊断算法快速诊断吡嗪酰胺耐药的耐多药结核病。
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10
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塔斯马尼亚首例确诊的多重耐药菌分离株的基因组序列草图

Draft Genome Sequence of the First Confirmed Isolate of Multidrug-Resistant in Tasmania.

作者信息

Gautam Sanjay S, Mac Aogáin Micheál, O'Toole Ronan F

机构信息

School of Medicine, Faculty of Health, University of Tasmania, Hobart, Tasmania, Australia.

Department of Clinical Microbiology, School of Medicine, Trinity College Dublin, St. James's Hospital, Dublin, Ireland.

出版信息

Genome Announc. 2017 Nov 2;5(44):e01230-17. doi: 10.1128/genomeA.01230-17.

DOI:10.1128/genomeA.01230-17
PMID:29097470
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5668546/
Abstract

The spread of multidrug-resistant (MDR) tuberculosis (TB) has become a major global challenge. In 2016, Tasmania recorded its first known incidence of MDR-TB. Here, we report the draft whole-genome sequence of the isolate from this case, TASMDR1, and describe single-nucleotide polymorphisms associated with its drug resistance.

摘要

耐多药结核病（MDR-TB）的传播已成为一项重大的全球挑战。2016年，塔斯马尼亚记录了其首例已知的耐多药结核病发病情况。在此，我们报告了该病例分离株TASMDR1的全基因组序列草图，并描述了与其耐药性相关的单核苷酸多态性。