Division of Internal Medicine, Fukuoka Dental College, Fukuoka, Japan.
Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Sci Rep. 2017 Nov 2;7(1):14901. doi: 10.1038/s41598-017-14205-2.
The association between blood urea nitrogen to creatinine ratio (UCR) and survival is uncertain in hemodialysis patients. We examined the influence of UCR on mortality and morbidity in hemodialysis patients. A total of 3,401 hemodialysis patients were prospectively followed for 4 years. The association between UCR with overall survival was analyzed using a Cox regression model. During a 4-year follow-up period, 545 patients died from any cause and 582 experienced MACE, 392 with coronary heart disease (CHD), 114 with infection-related death, 77 with hemorrhagic stroke, 141 with ischemic stroke, and 107 with cancer death. Every 1 increase in UCR level was significantly associated with an increased risk for all-cause mortality (hazard ratio [HR] 1.07; 95% confidence interval [CI] 1.03-1.12), CHD (HR 1.08; 95% CI 1.02-1.14), and infection-related death (HR 1.11; 95% CI 1.02-1.21). There was no evidence of a significant association between UCR and death from cancer, and incidence of stroke. A high UCR was significantly associated with an increased risk for all-cause mortality, infection-related death and incidence of CHD in hemodialysis patients.
血尿素氮与肌酐比值（UCR）与生存的关系在血液透析患者中尚不确定。我们研究了 UCR 对血液透析患者死亡率和发病率的影响。共有 3401 名血液透析患者前瞻性随访 4 年。使用 Cox 回归模型分析 UCR 与总生存率的关系。在 4 年的随访期间，545 名患者因任何原因死亡，582 名患者发生主要不良心血管事件（MACE），392 名患者患有冠心病（CHD），114 名患者因感染相关死亡，77 名患者患有出血性中风，141 名患者患有缺血性中风，107 名患者患有癌症死亡。UCR 水平每增加 1，全因死亡率（风险比 [HR] 1.07；95%置信区间 [CI] 1.03-1.12）、CHD（HR 1.08；95% CI 1.02-1.14）和感染相关死亡（HR 1.11；95% CI 1.02-1.21）的风险显著增加。UCR 与癌症死亡和中风发病率之间没有明显的关联。高 UCR 与血液透析患者全因死亡率、感染相关死亡和 CHD 发病率的增加风险显著相关。
