Clinical Laboratory, Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.
Division of Medical Practice, Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.
Biomed Res Int. 2017;2017:5450829. doi: 10.1155/2017/5450829. Epub 2017 Oct 2.
The diagnosis of infection (CDI) increases concern that asymptomatic carriers of toxigenic may be diagnosed with CDI.
A matched case control study was conducted in inpatients in a tertiary care center. The first 50 patients with diarrhea and a positive polymerase chain reaction (PCR) test beginning February 1, 2015, were identified as cases. Control patients were hospitalized patients receiving antibiotics, but with no diarrhea, housed in a room as close as possible to each case during the same admission time. A convenience sample of healthcare workers who cared for infected patients was also tested.
We found two positive PCR results for in controls (4.1%). None of these healthcare workers were positive for by PCR. There was no difference between groups with respect to overall antibiotic use before the requested PCR for ( = 0.359). The majority of cases had a high proportion of gastrointestinal disorders (71.4%) compared with control (8.2%), < 0.001. Patients with neoplasia had a higher chance of being identified as cases ( = 0.041).
PCR should not be the only diagnostic tool but should be complementary to other methods and to the medical history.
感染（CDI）的诊断增加了对可能被诊断为 CDI 的产毒 无症状携带者的关注。
在一家三级保健中心对住院患者进行了匹配的病例对照研究。2015 年 2 月 1 日起，将第 50 位出现腹泻和聚合酶链反应（PCR）检测阳性的患者确定为病例。对照患者为接受抗生素治疗但无腹泻的住院患者，与同一入院时间内的每个病例尽可能住在同一病房。还对照顾 感染患者的医护人员进行了方便抽样检测。
我们在对照组中发现了两个阳性的 PCR 结果（4.1%）。这些医护人员中没有人通过 PCR 检测出 。在请求进行 PCR 检测 之前，两组患者的总体抗生素使用情况无差异（ = 0.359）。与对照组（8.2%）相比，大多数病例有较高比例的胃肠道疾病（71.4%），差异具有统计学意义（ ＜0.001）。患有肿瘤的患者更有可能被确定为病例（ = 0.041）。
PCR 不应是唯一的诊断工具，而应与其他方法和病史互补。
