Academic Rheumatology, Musculoskeletal Research Unit, School of Clinical Sciences, Southmead Hospital, University of Bristol, Westbury-on-Trym, Bristol, BS10 5NB, UK.
Department of Medicine, College of Medicine, Wasit University, Kut, Iraq.
Osteoporos Int. 2018 Jan;29(1):19-29. doi: 10.1007/s00198-017-4287-6. Epub 2017 Nov 3.
Previous work has shown that patients with vertebral fractures do less physical activity. However, the association between vertebral fracture and different components of physical activity is unclear. Our results suggest that vertebral fracture (VF) is associated with a reduction in activities involving bending, ambulation, and daily living, regardless of age.
The aim of this study was to determine whether osteoporotic VF is associated with reduced self-reported everyday routine physical activity and/or ability (PAA).
A comprehensive search was undertaken using the databases of PubMed, Embase, Medline, Web of Science, and the "grey" literature from 1950 to the end of July 2016. Standardised search terms for VF and PAAs were used. Four categories of PAA were included: (1) bending ability, (2) ambulatory activities, (3) reaching arms above shoulder level, and (4) activities of daily living (ADLs). Strict inclusion and exclusion criteria were used, and only studies that adjusted for age were included. For the meta-analysis, pooled OR and 95% confidence interval (CI) were calculated using a random-effects model.
Eleven studies in total were identified which had investigated the associations between the prevalent VF and the selected PAAs and expressed these as ORs or RR. Women (six studies) with VF had a 64% increase in difficulty forward bending compared to those without VF. Women (nine studies) with VF had a 27% increase in difficulty doing ambulatory activities, while no association was observed for men (four studies). Women also have 73% (five studies), 127% (three studies), and 100% (four studies) increase in difficulty reaching arms above shoulder, shopping, and preparing meals, respectively.
Studies consistently show women with VF have reduced everyday activities, while much less research has been carried out in men. This information may be useful when designing interventions to improve physical function in people with osteoporotic VFs.
本研究旨在确定骨质疏松性椎体骨折（VF）是否与日常活动减少有关。
使用 PubMed、Embase、Medline、Web of Science 和 2016 年 7 月底前的“灰色”文献数据库进行全面检索。使用了 VF 和 PAAs 的标准化搜索词。纳入了 4 类 PAA：（1）弯腰能力，（2）步行活动，（3）手臂举过肩，（4）日常生活活动（ADL）。使用了严格的纳入和排除标准，仅纳入了调整年龄的研究。对于荟萃分析，使用随机效应模型计算了合并的 OR 和 95%置信区间（CI）。
共确定了 11 项研究，这些研究调查了现患 VF 与选定的 PAAs 之间的关联，并将这些关联表示为 OR 或 RR。与无 VF 的女性相比，有 VF 的女性向前弯腰困难增加了 64%。有 VF 的女性（9 项研究）步行活动困难增加了 27%，而男性（4 项研究）则无关联。女性在手臂举过肩、购物和准备饭菜方面的困难也分别增加了 73%（5 项研究）、127%（3 项研究）和 100%（4 项研究）。
研究一致表明，女性 VF 患者日常活动减少，而男性的研究较少。当设计改善骨质疏松性 VF 患者的身体功能的干预措施时，这些信息可能有用。
