Icelandic Heart Association Research Institute, Kopavogur, Iceland.
Age Ageing. 2012 May;41(3):351-7. doi: 10.1093/ageing/afs003. Epub 2012 Feb 23.
understanding the determinants of health burden after a fracture in ageing populations is important.
assess the effect of clinical vertebral and other osteoporotic fractures on function and the subsequent risk of hospitalisation.
individuals from the prospective population-based cohort study Age, Gene/Environment Susceptibility (AGES)-Reykjavik study were examined between 2002 and 2006 and followed up for 5.4 years.
a total of 5,764 individuals, 57.7% women, born 1907-35, mean age 77.
four groups with a verified fracture status were used; vertebral fractures, other osteoporotic fractures excluding vertebral, non-osteoporotic fractures and not-fractured were compared and analysed for the effect on mobility, strength, QoL, ADL, co-morbidity and hospitalisation.
worst performance on functional tests was in the vertebral fracture group for women (P < 0.0001) and the other osteoporotic fractures group for men (P < 0.05). Both vertebral and other osteoporotic fractures, showed an increased risk of hospitalisation, HR = 1.4 (95% CI: 1.3-1.7) and 1.2 (95% CI: 1.1-1.2) respectively (P < 0.0001). Individuals with vertebral fractures had 50% (P < 0.0001) longer hospitalisation than not-fractured and 33% (P < 0.002) longer than the other osteoporotic fractures group.
individuals with a history of clinical vertebral fracture seem to carry the greatest health burden compared with other fracture groups, emphasising the attention which should be given to those individuals.
了解老龄化人群骨折后健康负担的决定因素很重要。
评估临床椎体和其他骨质疏松性骨折对功能的影响以及随后住院的风险。
在 2002 年至 2006 年期间对前瞻性人群为基础的队列研究 Age, Gene/Environment Susceptibility (AGES)-Reykjavik 研究中的个体进行了检查，并随访了 5.4 年。
共有 5764 名个体，57.7%为女性，出生于 1907-35 年，平均年龄为 77 岁。
使用了具有验证骨折状态的 4 个组；椎体骨折、其他骨质疏松性骨折（不包括椎体）、非骨质疏松性骨折和未骨折，比较并分析了对移动性、力量、QoL、ADL、合并症和住院的影响。
在女性中，功能测试中最差的表现是在椎体骨折组（P<0.0001），而在男性中则是在其他骨质疏松性骨折组（P<0.05）。椎体和其他骨质疏松性骨折都增加了住院的风险，HR 分别为 1.4（95%CI：1.3-1.7）和 1.2（95%CI：1.1-1.2）（P<0.0001）。有椎体骨折的个体的住院时间比未骨折的个体长 50%（P<0.0001），比其他骨质疏松性骨折组长 33%（P<0.002）。
与其他骨折组相比，有临床椎体骨折史的个体似乎承担着更大的健康负担，这强调了应该给予这些个体更多的关注。
