Xie Xiaochuan, Shi Xiaohan, Liu Meilin
Department of Geriatrics, Peking University First Hospital, No. 8 Xishiku Street, Xicheng District, Beijing, 100034, China.
Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, 100191, China.
Pediatr Cardiol. 2018 Feb;39(2):207-225. doi: 10.1007/s00246-017-1760-0. Epub 2017 Nov 2.
This systematic review and meta-analysis aimed to better elucidate the roles of genetic factors in Kawasaki disease (KD), and determine the potential genetic biomarkers of KD. The systematic literature search of PubMed, Medline, Embase, Web of Science and CNKI identified 164 eligible studies. The qualitative synthesis revealed that 62 genes may be correlated with the susceptibility to KD, and 47 genes may be associated with the incidence of coronary artery lesions (CALs) in KD. A total of 53 polymorphisms in 34 genes were investigated in further quantitative synthesis. Of these, 23 gene polymorphisms were found to be significantly correlated with KD susceptibility, and 10 gene polymorphisms were found to be significantly associated with the incidence of CALs in KD. In conclusion, our findings indicate that gene polymorphisms of ACE, BLK, CASP3, CD40, FCGR2A, FGβ, HLA-E, IL1A, IL6, ITPKC, LTA, MPO, PD1, SMAD3, CCL17 and TNF may affect KD susceptibility. Besides, genetic variations in BTNL2, CASP3, FCGR2A, FGF23, FGβ, GRIN3A, HLA-E, IL10, ITPKC and TGFBR2 may serve as biomarkers of CALs in KD.
本系统评价和荟萃分析旨在更好地阐明遗传因素在川崎病（KD）中的作用，并确定KD的潜在遗传生物标志物。通过对PubMed、Medline、Embase、Web of Science和中国知网进行系统的文献检索，共识别出164项符合条件的研究。定性综合分析显示，62个基因可能与KD易感性相关，47个基因可能与KD冠状动脉病变（CALs）的发生有关。在进一步的定量综合分析中，对34个基因中的53个多态性进行了研究。其中，发现23个基因多态性与KD易感性显著相关，10个基因多态性与KD中CALs的发生显著相关。总之，我们的研究结果表明，ACE、BLK、CASP3、CD40、FCGR2A、FGβ、HLA-E、IL1A、IL6、ITPKC、LTA、MPO、PD1、SMAD3、CCL17和TNF的基因多态性可能影响KD易感性。此外，BTNL2、CASP3、FCGR2A、FGF23、FGβ、GRIN3A、HLA-E、IL10、ITPKC和TGFBR2的基因变异可能作为KD中CALs的生物标志物。
