分枝杆菌甘露糖磷酸肌醇对小鼠腹腔巨噬细胞的激活作用。
Activation of mouse peritoneal macrophages by mannophosphoinositides of mycobacteria.
作者信息
Mehta P K, Khuller G K
机构信息
Department of Biochemistry, Postgraduate Institute of Medical Education and Research, Changigarh, India.
出版信息
Med Microbiol Immunol. 1989;178(1):21-7. doi: 10.1007/BF00202288.
Peritoneal macrophages isolated from mannoside-methylated bovine serum albumin (MBSA)-immunized mice showed significantly enhanced phagocytosis of Mycobacterium smegmatis compared to control or MBSA-immunized groups. Immune macrophages also exhibited bacteriostatic activity against M. smegmatis. Pretreatment of mycobacteria with mannoside antibodies did not further alter the phagocytosis and bacteriostatic effect of immune macrophages.
与对照组或甘露糖苷甲基化牛血清白蛋白（MBSA）免疫组相比，从经MBSA免疫的小鼠中分离出的腹腔巨噬细胞对耻垢分枝杆菌的吞噬作用显著增强。免疫巨噬细胞对耻垢分枝杆菌也表现出抑菌活性。用甘露糖苷抗体预处理分枝杆菌不会进一步改变免疫巨噬细胞的吞噬作用和抑菌效果。
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