麻风分枝杆菌酚糖脂I的血清学特异性及其在麻风病血清诊断中的应用。
Serological specificity of phenolic glycolipid I from Mycobacterium leprae and use in serodiagnosis of leprosy.
作者信息
Cho S N, Yanagihara D L, Hunter S W, Gelber R H, Brennan P J
出版信息
Infect Immun. 1983 Sep;41(3):1077-83. doi: 10.1128/iai.41.3.1077-1083.1983.
Abstract
The serological activities of the specific phenolic glycolipid I from Mycobacterium leprae, its dissected parts, and related glycolipids from other mycobacteria were examined by enzyme-linked immunosorbent assay against hyperimmune anti-M. leprae rabbit antiserum and sera from patients with leprosy and other mycobacterial diseases. High anti-phenolic glycolipid I immunoglobulin M antibodies were found in 23 of 24 (96%) of lepromatous leprosy patients on short term chemotherapy and in 8 of 13 tuberculoid leprosy patients (62%). Sera from patients with tuberculosis or atypical mycobacterial infections were devoid of anti-phenolic glycolipid I activity. The structurally related phenolic glycolipids from Mycobacterium kansasii and Mycobacterium bovis and the aglycone segments of the M. leprae product showed no significant activity. Thus, the trisaccharide determinant of phenolic glycolipid I is specific in its structure, serological activity, and, to a lesser extent, the antibody class it evokes.
摘要
采用酶联免疫吸附试验，以针对麻风分枝杆菌的超免疫兔抗血清以及麻风病患者和其他分枝杆菌病患者的血清，检测了来自麻风分枝杆菌的特异性酚糖脂I、其分解部分以及来自其他分枝杆菌的相关糖脂的血清学活性。在接受短期化疗的24例瘤型麻风患者中有23例（96%）以及13例结核样型麻风患者中有8例（62%）发现了高抗酚糖脂I免疫球蛋白M抗体。肺结核或非典型分枝杆菌感染患者的血清缺乏抗酚糖脂I活性。来自堪萨斯分枝杆菌和牛分枝杆菌的结构相关酚糖脂以及麻风分枝杆菌产物的苷元部分未显示出明显活性。因此，酚糖脂I的三糖决定簇在其结构、血清学活性以及在较小程度上在其所引发的抗体类别方面具有特异性。
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