From the Department of Critical Care Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Science, Beijing, China.
Department of Translational Physiology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.
Anesth Analg. 2018 May;126(5):1747-1754. doi: 10.1213/ANE.0000000000002620.
Colloid solutions have been advocated for use in treating hypovolemia due to their expected effect on improving intravascular retention compared with crystalloid solutions. Because the ultimate desired effect of fluid resuscitation is the improvement of microcirculatory perfusion and tissue oxygenation, it is of interest to study the effects of colloids and crystalloids at the level of microcirculation under conditions of shock and fluid resuscitation, and to explore the potential benefits of using colloids in terms of recruiting the microcirculation under conditions of hypovolemia. This article reviews the physiochemical properties of the various types of colloid solutions (eg, gelatin, dextrans, hydroxyethyl starches, and albumin) and the effects that they have under various conditions of hypovolemia in experimental and clinical scenarios.
胶体溶液因其在改善血管内潴留方面的预期效果而被推荐用于治疗低血容量，与晶体溶液相比。由于液体复苏的最终理想效果是改善微循环灌注和组织氧合，因此研究休克和液体复苏条件下胶体和晶体在微循环水平上的作用，并探讨在低血容量条件下使用胶体招募微循环的潜在益处，这是很有趣的。本文综述了各种类型的胶体溶液（如明胶、右旋糖酐、羟乙基淀粉和白蛋白）的理化特性，以及它们在实验和临床情况下各种低血容量条件下的作用。
