EA4294, Unité de Virologie Clinique et Fondamentale, Centre Universitaire de Recherche en Santé, Centre Hospitalier Universitaire et Université de Picardie Jules Verne, 80054 Amiens, France.
Viruses. 2017 Nov 3;9(11):327. doi: 10.3390/v9110327.
The BK virus (BKPyV) is a member of the family first isolated in 1971. BKPyV causes frequent infections during childhood and establishes persistent infections with minimal clinical implications within renal tubular cells and the urothelium. However, reactivation of BKPyV in immunocompromised individuals may cause serious complications. In particular, with the implementation of more potent immunosuppressive drugs in the last decade, BKPyV has become an emerging pathogen in kidney and bone marrow transplant recipients where it often causes associated nephropathy and haemorrhagic cystitis, respectively. Unfortunately, no specific antiviral against BKPyV has been approved yet and the only therapeutic option is a modulation of the immunosuppressive drug regimen to improve immune control though it may increase the risk of rejection. A better understanding of the BKPyV life cycle is thus needed to develop efficient treatment against this virus. In this review, we provide an update on recent advances in understanding the biology of BKPyV.
BK 病毒（BKPyV）是多瘤病毒科的一种成员，于 1971 年首次分离得到。BKPyV 在儿童时期频繁感染，并在肾小管细胞和尿路上皮中建立持续感染，但临床意义不大。然而，免疫功能低下者 BKPyV 的再激活可能会导致严重的并发症。特别是在过去十年中，更有效的免疫抑制剂的应用，BKPyV 已成为肾和骨髓移植受者中的一种新兴病原体，分别导致相关的肾病和出血性膀胱炎。不幸的是，目前还没有针对 BKPyV 的特效抗病毒药物，唯一的治疗选择是调节免疫抑制剂的治疗方案，以改善免疫控制，但这可能会增加排斥反应的风险。因此，为了开发针对这种病毒的有效治疗方法，我们需要更好地了解 BKPyV 的生命周期。在这篇综述中，我们提供了对 BKPyV 生物学的最新进展的了解。
