位置、位置、位置：定义黑色素瘤起源细胞的时空线索。
Location, Location, Location: Spatio-Temporal Cues That Define the Cell of Origin in Melanoma.
机构信息
Melanoma Laboratory, Molecular Oncology Programme, Spanish National Cancer Research Center (CNIO), 28029 Madrid, Spain.
MRC Institute of Genetics and Molecular Medicine, MRC Human Genetics Unit and University of Edinburgh Cancer Research UK Centre, Western General Hospital, EH4 2XR Edinburgh, UK.
出版信息
Cell Stem Cell. 2017 Nov 2;21(5):559-561. doi: 10.1016/j.stem.2017.10.009.
It is unclear whether melanoma initiates from mature melanocytes or stem cell precursors. In this issue of Cell Stem Cell, Moon et al. (2017) and Köhler et al. (2017) use in vivo lineage tracing to demonstrate that these two possibilities may occur downstream of the same pro-tumorigenic lesions, depending on environmental factors or the anatomical location.
目前尚不清楚黑色素瘤是起源于成熟的黑色素细胞还是干细胞前体。在本期的《Cell Stem Cell》杂志上，Moon 等人（2017）和 Köhler 等人（2017）利用体内谱系追踪技术证明，这两种可能性可能发生在同一促瘤病变的下游，具体取决于环境因素或解剖位置。
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