Xu Zhe, Shi Ping, Yibulayin Feiluore, Feng Lei, Zhang Hao, Wushou Alimujiang
Department of Stomatology, Shenzhen Longhua District Central Hospital, Guangdong Medical University, Shenzhen, Guangdong 518110, P.R. China.
Department of Oral and Maxillofacial Surgery, Shanghai Stomatological Hospital, Fudan University, Shanghai 200001, P.R. China.
Oncol Lett. 2018 Oct;16(4):5091-5099. doi: 10.3892/ol.2018.9247. Epub 2018 Aug 1.
Spindle cell melanoma (SCM) is a rare morphological subtype of melanoma, which is relatively uncharacterized. The aim of the present study was to investigate the incidence of SCM, its general demographics, basic clinico-pathologic features, treatment outcomes and disease-specific prognostic factors. SCM cases were sampled from the Surveillance, Epidemiology and End Results (SEER) Program (1973-2017). A total of 4761 SCM cases were identified, with a median age of 66 years. The female:male ratio was 0.62:1. Statistically significant overall survival (OS) and disease-specific survival (DSS) rate differences were identified depending on age, sex, ethnicity, tumor location, T stage, N stage, M stage, pathological grade, AJCC stage, SEER stages and surgical treatment (P<0.05). Multivariate Cox regression analysis revealed that age >66 years, T3+T4 stage disease, positive N stage and SEER historic stage of regional and distant metastasis tumor were associated with poor DSS and OS rates. In summary, SCM was most common in Caucasian people of 60~80 years of age with a predominance in males. Patient's age, ethnicity, T stage, N stage, and SEER historic stage were identified as independent prognostic factors of SCM in terms of DSS and OS.
梭形细胞黑色素瘤（SCM）是黑色素瘤一种罕见的形态学亚型，其特征相对不明确。本研究的目的是调查SCM的发病率、一般人口统计学特征、基本临床病理特征、治疗结果和疾病特异性预后因素。SCM病例取自监测、流行病学和最终结果（SEER）计划（1973 - 2017年）。共识别出4761例SCM病例，中位年龄为66岁。女性与男性比例为0.62:1。根据年龄、性别、种族、肿瘤位置、T分期、N分期、M分期、病理分级、美国癌症联合委员会（AJCC）分期、SEER分期和手术治疗，确定了具有统计学意义的总生存（OS）率和疾病特异性生存（DSS）率差异（P<0.05）。多因素Cox回归分析显示，年龄>66岁、T3 + T4期疾病、N分期阳性以及区域和远处转移肿瘤的SEER历史分期与不良的DSS率和OS率相关。总之，SCM在60至80岁的白种人中最为常见，男性居多。就DSS和OS而言，患者的年龄、种族、T分期、N分期和SEER历史分期被确定为SCM的独立预后因素。
