Grichnik James M, Ross Andrew L, Schneider Samantha L, Sanchez Margaret I, Eller Mark S, Hatzistergos Konstantinos E
Department of Dermatology and Cutaneous Surgery, University of Miami, Miller School of Medicine, Miami, FL, USA; Sylvester Comprehensive Cancer Center, University of Miami, Miller School of Medicine, Miami, FL, USA; Interdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine, Miami, FL, USA.
Exp Dermatol. 2014 May;23(5):310-3. doi: 10.1111/exd.12363. Epub 2014 Apr 2.
Melanocytic neoplasms are a diverse group of benign and malignant tumors with variable clinical features. While some models still promote the epidermal melanocyte as the origin of melanocytic neoplasms, clinical findings are inconsistent with this theory for the majority of tumors. Despite advances in naevus and melanoma biology, the location and differentiation status of the cell of origin remains undefined. Germ line genetics, biological state and cellular location of the mutated cell, as well as local environmental factors all likely play a role in the development of melanocytic neoplasms. Herein, we will review potential models for melanocytic neoplasia and discuss research challenges and opportunities.
黑素细胞肿瘤是一组具有多样临床特征的良性和恶性肿瘤。虽然一些模型仍将表皮黑素细胞视为黑素细胞肿瘤的起源，但大多数肿瘤的临床发现与该理论并不一致。尽管在痣和黑色素瘤生物学方面取得了进展，但肿瘤起源细胞的位置和分化状态仍不明确。种系遗传学、突变细胞的生物学状态和细胞位置，以及局部环境因素都可能在黑素细胞肿瘤的发生发展中起作用。在此，我们将综述黑素细胞肿瘤形成的潜在模型，并讨论研究挑战和机遇。
