Faraji-Goodarzi Mojgan, Taee Nadereh, Mohammadi-Kamalvand Mehrnoosh
Faculty of Medicine, Department of Pediatrics, Lorestan University of Medical Sciences, Khorramabad, Iran.
Student Committee research, Lorestan University of Medical Sciences, Khorramabad, Iran.
Drug Res (Stuttg). 2018 Apr;68(4):185-188. doi: 10.1055/s-0043-118537. Epub 2017 Nov 3.
Croup is a clinical syndrome which included inspiratory stridor, coughing with a dog-like sound, noise obstruction and respiratory distress symptoms. This present study was conducted to compare the effects of cold drink and dexamethasone, and the effects of their co-administration on children's croup.
In this study, all patients with croup admitted to the emergency ward of Madani Hospital Khorramabad were divided through the simple randomized method into 3 groups after informed consents were taken from their parents. The first group was given cold drink, second group with dexamethasone (DM), and the third group were given the combined treatment simultaneously. The patients in the first and second groups who did not show signs of improvement received the simultaneous treatment similar to the third group. The data were analyzed using the SPSS software through descriptive statistics and inferential statistics including multi-field variance analysis and co-variance analysis.
The results of the study indicated a statistically significant between the 3 group in terms of improvement time-scale of croup clinical symptoms (P=0.001). There was no significant difference observed between the effects of other variables on improvement time-scale of croup clinical symptoms.
The cold drink has less treating effect than DM and combined simultaneous treatment method. Also, DM had more influence than simultaneous treatment method. In addition, other variables including age, sex, birth weight, BMI, respiratory allergy and previous croup history did not influenced improvement time-scale and only type of intervention influenced improvement time-scale of croup clinical symptoms.
哮吼是一种临床综合征,包括吸气性喘鸣、犬吠样咳嗽、气道阻塞和呼吸窘迫症状。本研究旨在比较冷饮和地塞米松的效果,以及它们联合使用对儿童哮吼的影响。
在本研究中,霍拉马巴德马丹尼医院急诊科收治的所有哮吼患者在获得其父母的知情同意后,通过简单随机方法分为3组。第一组给予冷饮,第二组给予地塞米松(DM),第三组同时给予联合治疗。第一组和第二组中未显示改善迹象的患者接受与第三组类似的联合治疗。使用SPSS软件通过描述性统计和包括多因素方差分析和协方差分析在内的推断性统计对数据进行分析。
研究结果表明,3组在哮吼临床症状改善时间尺度方面存在统计学显著差异(P = 0.001)。其他变量对哮吼临床症状改善时间尺度的影响之间未观察到显著差异。
冷饮的治疗效果低于地塞米松和联合治疗方法。此外,地塞米松的影响大于联合治疗方法。此外,包括年龄、性别、出生体重、BMI、呼吸道过敏和既往哮吼病史在内的其他变量对改善时间尺度没有影响,只有干预类型影响哮吼临床症状的改善时间尺度。