Ahmadipour Shokoufeh, Salami-Khaneshan Aysan, Farahmand Fatemeh, Baharvand Parastoo
Department of Pediatric, Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran.
Hepatitis Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran.
Ann Med Surg (Lond). 2022 Jan 29;74:103302. doi: 10.1016/j.amsu.2022.103302. eCollection 2022 Feb.
Functional constipation (FC) and Gastroesophageal Reflux Disease (GERD) are common gastrointestinal disorders in children. The aim of this study is to investigate the correlation between functional constipation and GERD in children.
In this cross-sectional study, a total of 82 children aged <16 years who referred to the pediatric gastroenterology clinic of (XXX) and were diagnosed with functional constipation according to ROME III criteria, and gastroesophageal reflux disease according to clinical history and DeMeester Score. Questionnaire was used to obtain the data regarding age, sex, cause of the visit, presence or absence of any symptom was noted, clinical examinations and difficulty in defecation.
Of the 82 children with FC and GERD, 45 were boys and 37 were girls. Among children with FC and GERD, FC was reported in 50 (61%) cases prior to the onset of GERD, whereas 32 (39%) of the children had reflux before FC. The mean age of participants presented with FC was 5.66 ± 3.52 and that of GERD was 5.24 ± 2.83. The difference in mean age was not statistically significant. Of the children with gastroesophageal reflux disease, there were 13 (40.6%) males and 19 females while 32 (64%) males and 18 females had FC and the gender-based difference was statistically significant between the 2 groups.
The prevalence of functional constipation in children was higher than gastroesophageal reflux disease. Gastroesophageal reflux disease and functional constipation should be simultaneously considered for therapeutic interventions and patients with functional digestive diseases should be monitored and followed-up.
功能性便秘（FC）和胃食管反流病（GERD）是儿童常见的胃肠道疾病。本研究旨在探讨儿童功能性便秘与胃食管反流病之间的相关性。
在这项横断面研究中，共有82名年龄小于16岁的儿童转诊至（XXX）儿科胃肠病诊所，根据罗马III标准被诊断为功能性便秘，并根据临床病史和德梅斯特评分诊断为胃食管反流病。使用问卷获取有关年龄、性别、就诊原因、是否存在任何症状、临床检查和排便困难的数据。
在82例患有FC和GERD的儿童中，45例为男孩，37例为女孩。在患有FC和GERD的儿童中，50例（61%）报告在GERD发病前出现FC，而32例（39%）儿童在FC之前出现反流。出现FC的参与者的平均年龄为5.66±3.52岁，GERD的平均年龄为5.24±2.83岁。平均年龄差异无统计学意义。在患有胃食管反流病的儿童中，男性13例（40.6%），女性19例，而患有FC的男性32例（64%），女性18例，两组之间基于性别的差异具有统计学意义。
儿童功能性便秘的患病率高于胃食管反流病。在进行治疗干预时应同时考虑胃食管反流病和功能性便秘，对功能性消化疾病患者应进行监测和随访。
