Zhang Jing, Ren Qingqing, Song Yanlin, He Min, Zeng Yunhui, Liu Zhiyong, Xu Jianguo
Department of Neurosurgery, West China Hospital, Sichuan University West China School of Medicine, West China Hospital, Sichuan University, Chengdu, China.
Medicine (Baltimore). 2017 Nov;96(45):e8624. doi: 10.1097/MD.0000000000008624.
The aim of this study was to evaluate the prognostic role of neutrophil-lymphocyte ratio (NLR) in patients with acute ischemic stroke (AIS).
PubMed, Embase, Web of Science, Cochrane Library, and China National Knowledge Infrastructure were searched for potential eligible literature. The study characteristics and relevant data were extracted. Odds ratios (ORs) with 95% confidence intervals (CIs) were pooled to estimate the prognostic role of NLR in patients with AIS. Poor functional outcome was defined as modified Rankin Scale ≥ 3.
Nine studies with 2947 patients were included. The pooled OR of higher NLR for poor functional outcome at 3 months was 1.55 (95% CI, 1.21-2.00). The pooled ORs for death at 3 months, poor functional outcome at discharge, and symptomatic intracranial hemorrhage (sICH) were 2.35 (95% CI, 0.40-13.78), 2.38 (95% CI, 0.49-11.69), and 4.32 (95% CI, 2.46-7.61), respectively.
For patients with AIS, higher NLR was associated with poorer functional outcome at 3 months and may be associated with a higher risk of developing sICH. This readily available and inexpensive marker may be helpful in future clinical and research work. However, due to the limited number of included studies, more well-designed studies are warranted to further clarify this issue.
本研究旨在评估中性粒细胞与淋巴细胞比值（NLR）在急性缺血性卒中（AIS）患者中的预后作用。
检索了PubMed、Embase、Web of Science、Cochrane图书馆和中国知网，以查找潜在的符合条件的文献。提取了研究特征和相关数据。汇总了具有95%置信区间（CI）的比值比（OR），以评估NLR在AIS患者中的预后作用。不良功能结局定义为改良Rankin量表评分≥3分。
纳入了9项研究，共2947例患者。3个月时NLR升高与不良功能结局的汇总OR为1.55（95%CI，1.21-2.00）。3个月时死亡、出院时不良功能结局和症状性颅内出血（sICH）的汇总OR分别为2.35（95%CI，0.40-13.78）、2.38（95%CI，0.49-11.69）和4.32（95%CI，2.46-7.61）。
对于AIS患者，较高的NLR与3个月时较差的功能结局相关，并且可能与发生sICH的较高风险相关。这种易于获得且廉价的标志物可能有助于未来的临床和研究工作。然而，由于纳入研究的数量有限，需要更多设计良好的研究来进一步阐明这一问题。
